When comparing LipiGesic M to a comprehensive list published by the Cleveland Clinic of both over-the-counter and prescription formulations for the treatment of acute migraine headaches, it stands alone as a viable migraine treatment without risk of rebound headache. The extensive list that was published on the Cleveland Clinic website includes: "aspirin, sinus relief medications, acetaminophen, nonsteroidal anti-inflammatory medications (NSAIDs), sedatives for sleep, codeine and prescription narcotics, and over-the-counter combination headache remedies containing caffeine (such as Anacin ®, Excedrin ®, Bayer Select ®, and others)."Other medications commonly associated with rebound headaches are ergotamine preparations (Cafergot ®, Migergot ®, Ergomar ®, Bellergal-S ®, Bel-Phen-Ergot S ®, Phenerbel-S ®, Ercaf ®, Wigraine ® and Cafatine PB ®), butalbital combination analgesics (Goody's Headache Powder ®, Supac ®, Excedrin ®, Fiorinal ®) and opiates (codeine). The triptans – which are migraine-specific medications and include Imitrex ®, Zomig ®, Maxalt ®, Relpax ®, Axert ®, Frova ®, Amerge ®, and Treximet ® – taken more than 2 times per week can also cause rebound headaches." http://my.clevelandclinic.org/disorders/Headaches/hic_Rebound_Headaches.aspx Medication-overuse headache is related to common OTC medications. In the article, "Doctor Says Painkillers Cause Epidemic of Child Headaches," which was published on August 2, 2013 in the Herald Scotland, Dr. Ishaq Abu-Arafeh, who runs a headache clinic at the Royal Hospital for Sick Children in Yokhill, Glasgow, Scotland, states there has been an increase in children who are suffering from headaches because they are either consuming too much caffeine or too much paracetamol, which is known as acetaminophen in the U.S. Dr. Abu-Arafeh explained, "prolonged use of paracetamol and ibuprofen can dull pain for a short time but makes the head more sensitive and more likely to feel sore."