Another stock that's creeping up on triggering a major breakout trade is Repros Therapeutics ( RPRX), development stage biopharmaceutical player focused on the development of oral small molecule drugs for major unmet medical needs in male and female health. This stock is off to a strong start in 2013, with shares up by 24%. >>5 Summer Buy Signals From the Health Care Sector If you take a look at the chart for Repros Therapeutics, you'll notice that this stock has been uptrending strong for the last month and change, with shares moving higher from its low of $15.11 to its recent high of $21.02 a share. During that uptrend, shares of RPRX have been mostly making higher lows and higher highs, which is bullish technical price action. That move has now pushed shares of RPRX within range of triggering a major breakout trade. Market players should now look for long-biased trades in RPRX if it manages to break out above some near-term resistance levels at $20.08 to its 52-week high at $21.02 a share with high volume. Look for a sustained move or close above those levels with volume that registers near or above its three-month average action of 468,100 shares. If that breakout triggers soon, then RPRX will set up to enter new 52-week-high territory, which is bullish technical price action. Some possible upside targets off that breakout are $25 to $30, or even $35 a share. Traders can look to buy RPRX off any weakness to anticipate that breakout and simply use a stop that sits right below its 50-day moving average at $17.95 a share, or right below $17 a share. One could also buy RPRX off strength once it takes out those breakout levels with volume and then simply use a stop that sits a comfortable percentage from your entry point. This is another stock that's very popular among the short-sellers, since the current short interest as a percentage of the float for RPRX is extremely high at 19.2%. If RPRX can break out to new all-time highs soon with volume, then the shorts could be in serious trouble as momentum buyers swoop in to buy that bullish technical price action.