NEW YORK ( TheStreet) -- To invest in any big pharmaceutical company, you must investigate the reasons to own each specific stock in terms of its drug pipeline, patent issues and potential FDA decisions on the use of new drug therapies.Stock screening tools such as www.ValuEngine.com and the analysis of chart patterns cannot anticipate how a big pharma stock will react to a specific news release. ValuEngine data is based upon financial information based upon company filings. It is purely a quantitative analysis. Price charts for any stock measures the risk/reward for the ups and downs of the stock based upon price momentum and moving averages. My proprietary analytics distill the tug of war between the oil of equity fundamentals and the water of technical analysis. My models calculate value levels, pivots and risky levels that buy-and-trade investors can us to buy on weakness and sell on strength. In developing this discipline I have assumed that nine years of price data has anticipated all potential bullish or bearish events for any market or stock. If you know a big pharma company and what they do in the drug world you can maintain a core long position in the stock. Then you use ValuEngine ratings, simple moving averages and my proprietary analytics to add to positions on weakness and reduce positions on strength. Stocks continue to trade under a ValuEngine valuation warning with 70.3% of all stocks overvalued, 33.7% overvalued by 20% or more. We still show that 15 of 16 sectors are overvalued, 12 by double-digit percentages including today's featured medical sector, which is overvalued by17.1%. The large cap pharma industry is 16.4% overvalued. Among the 12 big pharma stocks in today's table four are undervalued and eight are overvalued with six overvalued by more than 20%. Ten stocks gained by 9.7% to 43.6% over the last 12 months with only two losing ground. The projected performances over the next 12 months range from a loss of 3.8% to a gain of 8.2%. The 12 month trailing price-to-earnings ratios show two stocks with single digit P/E and two with P/E above 20.0. Three stocks are below their 200-day simple moving averages, and nine are above, which indicates the risk of reversion to the mean.