By Derrik J. LangLOS ANGELES (AP) -- It's a blowout at the box office. Fast & Furious 6 is revving past The Hangover Part III in the No. 1 position at the Memorial Day weekend box office. Universal Pictures' ( CMCSA) sixth installment of its muscle car franchise featuring Vin Diesel and Paul Walker debuted with $98.5 million domestically from Friday to Sunday, according to studio estimates Sunday. Meanwhile, the final edition of the raunchy Warner Bros. ( TWX) comedy trilogy starring Zach Galifianakis, Bradley Cooper and Ed Helms opened with $42.1 million in the No. 2 spot. Universal estimates that by the end of the four-day holiday weekend Monday, Fast & Furious 6 will have pulled in $122.2 million domestically and $275.5 million worldwide. That would give it the second-biggest opening of the year behind Iron Man 3. Paramount Pictures' ( VIA) sci-fi sequel Star Trek: Into Darkness earned $38 million at No. 3 in its second weekend at the box office, while the Fox animated film Epic opened at No. 4 with $34.2 million. Overall domestic receipts for the four-day Memorial Day weekend are expected to come in ahead of 2011's record-breaking $276 million. Paul Dergarabedian, an analyst for box-office tracker Hollywood.com, estimated that four-day revenues this time will total $323 million, about 15 percent above Memorial Day weekend in 2011, when The Hangover Part II delivered a $103.4 million debut.