One stock that's starting to move within range of triggering a major breakout trade is Supernus Pharmaceuticals ( SUPN), which is focused on developing and commercializing products for the treatment of central nervous system, or CNS, diseases. This stock has been under pressure by the sellers so far in 2013, with shares off by 18.6%. >>5 Stocks Insiders Love Right Now If you take a look at the chart for Supernus Pharmaceuticals, you'll notice that this stock has been uptrending for the last month, with shares moving higher from its low of $4.45 to its intraday high of $6.09 a share. During that uptrend, shares of SUPN have been consistently making higher lows and higher highs, which is bullish price action. That move has now pushed shares of SUPN back above its 50-day moving average at $5.52 a share, and the stock is now quickly moving within range of triggering a major breakout trade. Traders should now look for long-biased trades in SUPN if it manages to break out above some near-term overhead resistance levels at $5.68 to $6.29 a share with high volume. Look for a sustained move or close above those levels with volume that hits near or above its three-month average action of 438,265 shares. If that breakout triggers soon, then SUPN will set up to re-test or possibly take out its next major overhead resistance levels at $7 to $8 a share. Any high-volume move above $8.06 to $8.15 would then give SUPN a chance to re-fill some of its previous gap down zone from last December that started near $11 a share. Traders can look to buy SUPN off any weakness to anticipate that breakout and simply use a stop that sits right around its 50-day at $5.52 a share or right below $5 a share. One could also buy SUPN off strength once it takes out those breakout levels with volume and then simply use a stop right below its 50-day at $5.52 a share. This stock is a favorite target of the short-sellers, since the current short interest as a percentage of the float for SUPN is extremely high at $30.8%. The bears have also been increasing their bets from the last reporting period by 21.4%, or by about 750,000 shares. If this stock triggers that breakout soon, then the bears could get caught pressing their bets into a monster move higher.