MADISON, Wis. ( Stockpickr) -- Professional traders running mutual funds and hedge funds don't just look at a stock's price moves; they also track big changes in volume activity. Often when above-average volume moves into an equity, it precedes a large spike in volatility.Major moves in volume can signal unusual activity, such as insider buying or selling -- or buying or selling by "superinvestors." >>5 Hated Earnings Stocks That Deserve Your Love Unusual volume can also be a major signal that hedge funds and momentum traders are piling into a stock ahead of a catalyst. These types of traders like to get in well before a large spike, so it's always a smart move to monitor unusual volume. That said, remember to combine trend and price action with unusual volume. Put them all together to help you decipher the next big trend for any stock. With that in mind, let's take a look at several stocks rising on unusual volume today. >>Stocks Are Doomed. Buy More Stocks. Stemline Therapeutics Stemline Therapeutics ( STML) is a clinical-stage biopharmaceutical company focused on discovering, acquiring, developing and commercializing therapeutics that target both cancer stem cells and tumor bulk. This stock is trading up 6.9% at $14.44 in recent trading. Today's Volume: 110,000
Average Volume: 52,155
Volume % Change: 190% From a technical perspective, STML is soaring higher here and breaking out to a new all-time high above some past overhead resistance levels at $13.70 to $14.26 with above-average volume. At last check, STML has hit an intraday high of $14.50 and volume is well above its three-month average action of 52.155 shares. Traders should now look for long-biased trades in STML as long as it's trending above $13.70 or above $14.26 and then once it sustains a move or close its intraday high of $14.50 with volume that hits near or above 52,155 shares. If that breakout triggers soon, then STML will set up to enter new all-time high territory, which is bullish technical price action. Some possible upside targets off that move are $16 to $18. WuXi PharmaTech WuXi PharmaTech ( WX) is a pharmaceutical, biotechnology and medical device R&D outsourcing company, with operations in China and the U.S. This stock is trading up 3.2% at $18.99 in recent trading.