5. Transformers: Revenge of the FallenYear released: 2009 Overall U.S. box office gross: $402.1 million Yes, the Transformers were a Marvel comics property at one point, but these films have as much to do with those books as they had to do with the Hasbro ( HAS) toys and animated film from the '80s. Sure, Optimus Prime's voice is the same and some of the throwback elements made it into the first installment, but this sequel had a tough time keeping Shia LaBeouf and Megan Fox onscreen, never mind a few decades' worth of nostalgia. This is where the Transformers series pivots from a human tale featuring CGI machines and deep bass sound effects to a bunch of computer animation fighting onscreen almost nonstop and enough bass drops to blow out lesser theaters' speakers. The Transformers series' take would never be this big again, but it in 2009, it was enough to bludgeon Harry Potter, Up, The Hangover and Star Trek into submission.