Spring allergy score: 100 Mississippi's state capital is this year's U.S. capital for springtime allergies, too. Jackson placed fourth in the AAFA's 2012 study, but Tringale says the city moved up to No. 1 this year "due to very high pollen and allergy-medication indices. Both are significantly higher there than in other cities." Located in southwest Mississippi, Jackson has particularly bad problems with pollen from red cedar, hackberry, elm, willow and poplar trees. That said, the 539,000-population metro area does enjoy an above-average ratio of board-certified allergists to patients.