WINDERMERE, Fla. ( Stockpickr) -- Professional traders running mutual funds and hedge funds don't just look at a stock's price moves; they also track big changes in volume activity. Often when above-average volume moves into an equity, it precedes a large spike in volatility.Major moves in volume can signal unusual activity, such as insider buying or selling -- or buying or selling by "superinvestors." >>5 Hated Stocks to Buy to Beat the S&P in 2013 Unusual volume can also be a major signal that hedge funds and momentum traders are piling into a stock ahead of a catalyst. These types of traders like to get in well before a large spike, so it's always a smart move to monitor unusual volume. That said, remember to combine trend and price action with unusual volume. Put them all together to help you decipher the next big trend for any stock. With that in mind, let's take a look at several stocks rising on unusual volume today. >>5 Stocks Poised for Breakouts Clovis Oncology Clovis Oncology ( CLVS) is a biopharmaceutical company focused on acquiring, developing and commercializing innovative anti-cancer agents in the U.S., Europe and additional international markets. This stock is trading up 3.4% at $31.03 in recent trading. Today's Volume: 147,000 Average Volume: 93,464 Volume % Change: 154% >>5 Health Care Stocks Ready to Break Out From a technical perspective, CLVS is trending higher here and breaking out above some near-term overhead resistance at $29.53 with above-average volume. This move has pushed shares of CLVS into new 52-week-high and all-time-high territory, which is bullish technical price action. Traders should now look for long-biased trades in CLVS as long as it's trending above $29.53 or above today's low of $29.97 and then once it sustains a move or close above today's high of $31.08 with volume that hits near or above 93,464 shares. If that breakout hits soon, then CLVS will enter new all-time high territory and possibly have a chance of tagging $34 to $35. JDS Uniphase JDS Uniphase ( JDSU) is a provider of communications test and measurement solutions and optical products for telecommunications service providers, cable operators, and network equipment manufacturers. This stock is trading up 5.2% to $14.04 in recent trading.