earnings release. Sometimes stocks making big moves have been hit with an analyst upgrade or an analyst downgrade. >>5 Rocket Stocks You Should Buy as Stocks Drop Regardless of the reason behind it, when a stock makes a large-percentage move, it is often just the start of a new major trend -- a trend that can lead to huge profits. If you time your trade correctly, combining technical indicators with fundamental trends, discipline and sound money management, you will be well on your way to investment success. With that in mind, let's take a closer look at a several stocks that are making large moves to the upside today. >>5 Stocks Poised for Breakouts Durect Durect ( DRRX) is a specialty pharmaceutical company that develops pharmaceutical products based on its proprietary drug delivery technology platforms. This stock is trading up 7.4% to $1.30 in recent trading. Today's Range: $1.21-$1.31 52-Week Range: $0.61-$1.71 Volume: 267,000 Three-Month Average Volume: 321,195 From a technical perspective, DRRX is ripping higher here right above its 50-day moving average of $1.12 with decent upside volume. This move is quickly pushing shares of DRRX within range of triggering a major breakout trade. That trade will hit if DRRX manages to take out some key overhead resistance levels at $1.38 to $1.42 with high volume. Traders should now look for long-biased trades in DRRX as long as it's trending above today's low of $1.21 or above its 50-day at $1.12, and then once it sustains a move or close above those breakout levels with volume that hits near or above 321,195 shares. If that breakout triggers soon, then DRRX will set up to re-test or possibly take out its next major overhead resistance level at $1.71.