earnings release. Sometimes stocks making big moves have been hit with an analyst upgrade or an analyst downgrade. >>5 Huge Stocks to Trade for Gains Regardless of the reason behind it, when a stock makes a large-percentage move, it is often just the start of a new major trend -- a trend that can lead to huge profits. If you time your trade correctly, combining technical indicators with fundamental trends, discipline and sound money management, you will be well on your way to investment success. With that in mind, let's take a closer look at a several stocks that are making large moves to the upside today. >>5 Stocks With Big Insider Buying Opexa Therapeutics Opexa Therapeutics ( OPXA) is engaged in developing personalized cellular therapies with the potential to treat major illnesses, including multiple sclerosis. This stock closed up 3.4% to $2.12 in Thursday. Thursday's Range: $1.97-$2.23 52-Week Range: $1.07-$5.19 Volume: 300,000 Three-Month Average Volume: 373,233 From a technical perspective, OPXA bounced higher here right off its 200-day moving average of $2.05 with lighter-than-average volume. This stock has been downtrending badly for the last month, with shares dropping from its high of $5.19 to its recent low of $1.28. During that move, shares of OPXA were mostly making lower highs and lower lows, which is bearish technical price action. That said, OPXA has started to rebound off that $1.28 low and quickly moving within range of triggering a near-term breakout trade. That trade will hit if OPXA manages to take out some near-term overhead resistance at $2.26 to $2.48 and then above $2.74 with high volume. Traders should now look for long-biased trades in OPXA as long as it's trending above its 50-day at $1.75 and then once it sustains a move or close above those breakout levels with volume that hits near or above 373,233 shares. If that breakout hits soon, then OPXA will set up to re-test or possibly take out its next major overhead resistance level at $3.25. Any high-volume move above $3.25 will then give OPXA a chance to trade north of $4.