My final idea that's trending very close to triggering a near-term breakout trade is Threshold Pharmaceuticals ( THLD), which is a biotechnology company focused on the discovery and development of drugs targeting the microenvironment of solid tumors as novel treatments for patients living with cancer. This stock has been hit hard by the bears during the last six months, with shares off by 46%. If you look at the chart for Threshold Pharmaceuticals, you'll notice that this stock has started to uptrend for the last three months, with shares moving higher from its low of $4.04 to its high of $5.54 a share. During that uptrend, shares of THLD have been mostly making higher lows and higher highs, which is bullish technical price action. Shares of THLD are now trending just above its 50-day moving average of $4.53 a share and its quickly moving within range of triggering a near-term breakout trade above a key downtrend line. Traders should now look for long-biased trades in THLD if it manages to break out above some near-term overhead resistance levels at $5.13 to $5.54 a share with high volume. Look for a sustained move or close above those levels with volume that registers near or above its three-month average action of 883,888 shares. If that breakout triggers soon, then THLD will set up to re-test or possibly take out its next major overhead resistance levels at $5.90 to its 200-day at $5.96 a share. Any high-volume move above $5.96 will then put $6.50 to $7.50 into range for shares of THLD. Traders can look to buy THLD off any weakness to anticipate that breakout and simply use a stop that sits right below some near-term support levels at $4.36 to $4.28 a share. One could also buy THLD off strength once it takes out those breakout levels with volume and then simply use a stop that sits right below its 50-day moving average of $4.53 a share. This stock is a favorite target of the short-sellers, since its current short interest as a percentage of its float is rather high at 14.4%. The bears have also been increasing their bets from the last reporting period by 4.1%, or by about 251,000 shares. If that breakout triggers soon, then THLD has the potential for a monster short-squeeze. To see more breakout candidates, check out the Breakout Stocks of the Week portfolio on Stockpickr. -- Written by Roberto Pedone in Winderemere, Fla.