All Breakthrough Prize recipients will be invited to present public talks targeting a general audience. These lectures, together with supporting materials, will be made available to the public, allowing everyone to keep abreast of the latest developments in life sciences, guided by contemporary masters of the field.About the Breakthrough Prize Foundation: The Breakthrough Prize in Life Sciences Foundation is a not-for-profit corporation dedicated to advancing breakthrough research in life sciences, celebrating scientists and generating excitement about the pursuit of science as a career. Additional information about the Foundation and the 2013 recipients of the prizes can be found at http://www.breakthroughprizeinlifesciences.org. About the prize winners: Cornelia I. Bargmann Torsten N. Wiesel Professor and Head of the Lulu and Anthony Wang Laboratory of Neural Circuits and Behavior at the Rockefeller University. Howard Hughes Medical Institute Investigator. For the genetics of neural circuits and behavior, and synaptic guidepost molecules. David Botstein Director of the Lewis-Sigler Institute for Integrative Genomics and the Anthony B. Evnin Professor of Genomics at Princeton University. For linkage mapping of Mendelian disease in humans using DNA polymorphisms. Lewis C. Cantley Margaret and Herman Sokol Professor and Director of the Cancer Center at Weill Cornell Medical College and New York-Presbyterian Hospital. For the discovery of PI 3-Kinase and its role in cancer metabolism. Hans Clevers Professor of Molecular Genetics at Hubrecht Institute. For describing the role of Wnt signaling in tissue stem cells and cancer. Titia de Lange Leon Hess Professor, Head of the Laboratory of Cell Biology and Genetics, and Director of the Anderson Center for Cancer Research at the Rockefeller University. For research on telomeres, illuminating how they protect chromosome ends and their role in genome instability in cancer.