earnings release. Sometimes stocks making big moves have been hit with an analyst upgrade or an analyst downgrade. >>5 Hated Stocks Set to Soar on Earnings Regardless of the reason behind it, when a stock makes a large-percentage move, it is often just the start of a new major trend -- a trend that can lead to huge profits. If you time your trade correctly, combining technical indicators with fundamental trends, discipline and sound money management, you will be well on your way to investment success. With that in mind, let's take a closer look at a several stocks that are making large moves to the upside today. >>5 Rocket Stocks to Buy in February OxiGene OxiGene ( OXGN) is a clinical-stage biopharmaceutical company developing novel therapeutics to treat cancer and eye diseases. This stock is trading up 7% to $4.28 in recent trading. Today's Range: $4.26-$4.32 52-Week Range: $3.72-$16.20 Volume: 24,000 Three-Month Average Volume: 18,677 From a technical perspective, OXGN is ripping higher here right off some near-term support at $3.96 with above-average volume. This move is quickly pushing shares of OXGN within range of triggering a near-term breakout trade. That trade will hit if OXGN manages to take out its 50-day moving average of $4.59 and then some more overhead resistance at $4.90 with high volume. Traders should now look for long-biased trades in OXGN as long as it's trending above its $3.96, and then once it sustains a move or close above those breakout levels with volume that hits near or above 18,677 shares. If that breakout triggers soon, then OXGN will set up to re-test or possibly take out its next major overhead resistance levels at $6 to its 200-day moving average at $6.94.