“In the current standard of care with head and neck tumors, it is not uncommon to remove as many as 60 regional lymph nodes during bilateral neck dissection because of the likelihood that patients may have hidden cancer in the lymph nodes. Sentinel node biopsy allows for a much less invasive and more precise evaluation with reduced surgical side effects” said Dr. Civantos. “Our initial clinical experience with Lymphoseek suggested a high level of accuracy in the identification and mapping of SLNs that may significantly improve the precision and practicality of the procedure. We believe that Lymphoseek may also have special utility to improve localization in certain tumor types such as those found on the floor of the mouth. I fully expect the final results of the multi-institutional trial, when completed, will confirm these impressions.”

“The study of head and neck cancer is part of Navidea’s worldwide strategy to expand the utilization of Lymphoseek into multiple cancer types beyond breast cancer and melanoma and to assist physicians and patients in improving the accuracy of cancer diagnosis and staging,” said Dr. Reininger. “We believe that there are many unmet needs in the lymphatic mapping of other solid tumor cancers where the procedure may be highly useful, but for which a suitable agent has not yet been developed. Lymphoseek targets key predictive lymph nodes through its specifically-designed, receptor-based mechanism and can fill that need and enhance diagnostic accuracy.”

The satellite symposium, Sentinel Lymph Node (SLN) Biopsy in Head and Neck Cancer, was jointly sponsored with SurgicEye GmbH, Munich, Germany.

About Lymphoseek ®

Lymphoseek ® (technetium Tc 99m tilmanocept) Injection is a novel, receptor-targeted, small-molecule, investigational radiopharmaceutical used in lymphatic mapping procedures that are performed to help stage cancers such as breast cancer and melanoma. Lymphoseek is designed to identify the lymph nodes that drain from a primary tumor, which have the highest probability of harboring cancer.

Lymphatic mapping is a procedure in which lymph nodes that may contain tumor metastases are identified and biopsied to determine if cancer has spread beyond the primary tumor. Accurate staging of cancer is critical, as it guides therapy decisions and determines patient prognosis and risk of recurrence. According to the American Cancer Society, approximately 229,000 new cases of breast cancer, 76,000 new cases of melanoma and 67,000 new cases of head and neck cancers are expected to be diagnosed in the United States in 2012.

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