Another stock that's trending within range of triggering a major breakout trade is AcelRx Pharmaceuticals ( ACRX), a U.S.-based pharmaceutical company that develops and commercializes therapies for the treatment of pain. This stock has been blazing a trail to the upside so far in 2013, with shares up a whopping 24%. If you take a look at the chart for AcelRx Pharmaceuticals, you'll see that this stock has been uptrending very strong for the last two months, with shares soaring higher from its low of $3.30 to its recent high of $5.83 a share. During that uptrend, shares of ACRX have been consistently making higher lows and higher highs, which is bullish technical price action. That move has now pushed shares of ACRX within range of triggering a major breakout trade that would push the stock to new all-time highs. Market players should now look for long-biased trades in ACRX if it manages to break out above some near-term overhead resistance levels at $5.63 to $5.83 a share with high volume. Look for a sustained move or close above those levels with volume that registers near or above its three-month average action of 330,884 shares. If that breakout triggers soon, then ACRX will set up to enter new all-time highs, which is extremely bullish technical price action. This means that the stock will have no more overhead resistance levels to contend with. Some possible upside targets off that breakout are $8 to possible even $10 a share. Traders can look to buy ACRX off any weakness to anticipate that breakout and simply use a stop that sits just below its 50-day moving average of $4.41 a share. One could also buy off strength once ACRX clears those breakout levels with volume and then simply use a stop right around some key near-term support levels at $5.10 to $4.82 a share. This is another name that's popular among the short-sellers, since the current short interest as a percentage of the float for ACRX stands at 9.6%. The worst possible case for the bears is being short a stock that's printing new all-time highs. That means that every one of them is losing money, which is never a successful venture in the markets. Look for a monster short-squeeze if ACRX can breakout and trend into all-time territory with volume.