One name that's trending very close to triggering a major breakout trade is Nektar Therapeutics ( NKTR), which is a clinical-stage biopharmaceutical company developing a pipeline of drug candidates that utilize its PEGylation and polymer conjugate technology platforms, which are designed to improve the benefits of drugs for patients. This stock has been on fire so far in 2013, with shares up 17%. If you take a look at the chart for Nektar Therapeutics, you'll notice that this stock has been uptrending strong for the two months and change, with shares soaring from its low of $5.65 to its recent high of $9.58 a share. During that uptrend, shares of NKTR have been consistently making higher lows and higher highs, which is bullish technical price action. That move has now pushed shares of NKTR within range of triggering a major breakout trade. Traders should now look for long-biased trades in NKTR if it manages to break out above some near-term overhead resistance levels at $9.19 to $9.58 a share with high volume. Look for a sustained move or close above those levels with volume that hits near or above its three-month average action of 1.3 million shares. If that breakout triggers soon, then NKTR will set up to re-test or possibly take out its next major overhead resistance levels at $10.91 to $10.98 a share. Any high-volume move above those levels will then put $12 to $13 into range for shares of NKTR. Traders can look to buy NKTR off any weakness to anticipate that breakout and simply use a stop that sits right below some key near-term support at $8.46 a share or use its 200-day moving average at $8.17 a share. One could also buy off strength once NKTR takes out those breakout levels with volume and then simply use a stop that sits near $9 to $8.46 a share. This stock is pretty popular among short-sellers, since the current short interest as a percentage of its float sits at 9.3%. If that breakout triggers soon, then look for some of those bears to get squeezed out of their positions, which will send this stock screaming higher.