Ligand Pharmaceuticals Another biotechnology and drugs player that insiders are buying up a decent amount of stock in is Ligand Pharmaceuticals ( LGND), which is focused on drug discovery and early-stage development of pharmaceuticals. Insiders are buying this stock into some notable strength, since shares are up 30% in the last three months. Ligand Pharmaceuticals has a market cap of $398 million and an enterprise value of $423 million. This stock trades at a premium valuation, with a trailing price-to-earnings of 137.66 and a forward price-to-earnings of 51.18. Its estimated growth rate for this year is -88.5%, and for next year it's pegged at 550%. This is not a cash-rich company, since the total cash position on its balance sheet is $7.05 million and its total debt is $28.15 million. A beneficial owner just bought 39,600 shares, or about $783,000 worth of stock, at $19.78 per share. From a technical perspective, LGND is currently trending above both its 50-day and 200-day moving averages, which is bullish. This stock has been uptrending strong for the last three months, with shares soaring from its low of $14.75 a share to its recent high of $21.75 a share. During that uptrend, shares of LGND have been consistently making higher lows and higher highs, which is bullish technical price action. Shares of LGND have recently sold off from that $21.75 high and moved back towards its 50-day moving average of $19.83 a share. Traders who are bullish on LGND should now look for long-biased trades as long as it's trending above some key near-term support at $19.03, and then once it manages to break out above some near-term overhead resistance levels at $20.99 to $21.75 a share with high volume. Look for a sustained move or close above those levels with volume that hits near or above its three-month average action of 153,792 shares. If that breakout hits soon, then LGND will set up to enter new 52-week-high territory, which is bullish technical price action. Some possible upside targets off that breakout are $25 to $27 a share. Natural Resource Partners One coal player that insiders are jumping into big here is Natural Resource Partners ( NRP), which is engaged mainly in the business of owning and managing coal properties in the three coal-producing regions of the U.S.: Appalachia, the Illinois Basin and the Western U.S. Insiders are buying this stock into modest strength, since shares are up 3.6% in the last three months.