NEW YORK ( TheStreet) - Amazon ( AMZN) reports fourth-quarter earnings Tuesday, and while seemingly everyone (I use that loosely) bought something from the world's largest online retailer during the holiday shopping season, once again it all comes down to whether Amazon can actually make money selling knick-knacks and do-dads. In the fourth quarter of 2011, Amazon had razor thin operating margins of 1.5%. But many would like to see Amazon start to capitalize on the all spending it has done in recent years as it expands its footprint, adding several new warehouses and capacity around the world. Analysts polled by Thomson Reuters expect the Seattle-based retailer to earn 28 cents a share on $22.26 billion in revenue, in the fourth quarter. That's up from 2011, when Amazon earned 38 cents a share on $17.43 billion in sales. Results from eBay ( EBAY) and Google ( GOOG) Shopping should provide a boost to Amazon's results, said J.P. Morgan Internet analyst Doug Anmuth, who rated Amazon overweight with a $245 price target. "We remain positive on Amazon driven by continued share gains and top-line growth, though we believe extremely positive sentiment heading into earnings likely leaves less margin for error in the near term," Anmuth wrote in his note. Even though the holiday shopping screams Amazon, not all is rosy. ChannelAdvisor noted that Amazon's same-store sales decelerated, even though they are more than double the e-commerce growth rate. "According to ChannelAdvisor, Amazon same-store sales increased 38.5% y/y in 4Q, a slight deceleration from 40.4% y/y in 3Q, though we note that 4Q's growth rate is still more than double the overall e-commerce growth rate," notes Raymond James analyst Aaron Kessler. Amazon is notorious for cutting prices on everything it sells, including Amazon Web Services (AWS), hardware (Kindle Fire) and software, so any improvement in margins will be an important metric to watch. Guidance is also another key to the quarter. Amazon is famous for doing what Apple ( AAPL) used to do -- lowering expectations, then crushing them. Anmuth is looking for $16.93 billion in revenue for the first quarter, but believes Amazon could give a range of $15.3 billion to $17.3 billion, with consolidated operating segment income margin showing continued investments as the company expands its fulfillment and moves into new products.