When asked how Opko discovered the new formulation, Frost indicated it was one of many successful acquisitions his company has made over the years. He also cited Claros, an acquisition completed in October 2011, as another such highly lucrative deal. Okpo has also partnered with several larger drug makers and will share in the revenue on drugs developed through their combined efforts.

When asked what's next for his company, Frost said Opko is nearing completion of its 4K test for prostate health. He said investors should be looking for more on that front in the "near future."

Cramer continued his support for Opko, saying the company and Frost have a proven track record of creating value for their shareholders as well as an uncanny ability to spot and acquire small companies with breakthrough products before the big boys take notice.

Know Your IPO

In the "Know Your IPO" segment, Cramer took a look back at the top eight best-performing IPOs from 2012 to remind investors what a successful IPO is all about. What do these eight newly-minted stocks all have in common? In a word, growth. While the S&P 500 rose by 13.4% in 2012, the average IPO rose by 20.5%, with these notable exceptions.

Topping the list was Vipshop ( VIPS), a Chinese e-commerce company that delivered a 174% gain for the year. Proto Labs ( PRLB) came in second place, with a 146% gain for 2012. Cramer said this custom prototyping company has tons of growth potential.

Next up were Homestreet ( HMST), a community bank with a red-hot mortgage business, up 132%; and Guidewire ( GWRE), a software provider for insurance companies that rose by 129%.

Continuing down the list, Cramer said that Intercept Pharmaceuticals ( ICPT) provided investors with predictable growth and that stock rose by 128%, while Nationstar Mortgage ( NSM) was another slow and steady grower, up 121% for 2012.

Rounding out the list were Eloqua ( ELOQ), a marketing automation company, up 105% last year; and WageWorks ( WAGE), a company that manages employee flexible spending accounts. WageWorks rose 40% on its first day and ended the year up 98%.

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