Second Health Economics Study Reconfirms Test's Cost Effectiveness
- Conducted in collaboration with the Mayo Clinic Cancer Research Consortium, a prospectively designed study analyzed treatment decisions for 141 stage II, T3 MMR-proficient colon cancer patients across 17 sites demonstrating that the use of the Oncotype DX Colon Cancer test changed treatment decisions 45 percent of the time and led to an overall reduction in chemotherapy use.For patients whose treatment recommendations changed, treatment intensity decreased for more than 33 percent of patients (from chemotherapy to observation or from oxaliplatin-containing to non-oxaliplatin containing regimens) and increased for more than 11 percent of patients (from observation to any chemotherapy or from non-oxaliplatin containing to oxaliplatin-containing treatment). Abstract #453: "Prospective evaluation of a 12-gene assay on treatment recommendations in stage II colon cancer patients" will be presented on Saturday, January 26, from 7:00–7:55 a.m. Pacific Time at Moscone West, San Francisco, Calif.
Additionally, the company will present a poster titled: "Impact of the Recurrence Score (RS) result and mismatch repair status (MMR) on agreement between oncologists (MDs) for stage II colon cancer (CC) recurrence risk (RR) assessment: A novel clinical utility endpoint for prognostic markers" (Abstract #349) on Saturday, January 26, from 7:00 – 7:55 a.m. Pacific Time at Moscone West, San Francisco, Calif. Four leading medical specialty societies co-sponsor the three-day, multidisciplinary symposium, including the American Gastroenterological Association Institute, the American Society of Clinical Oncology, the American Society for Radiation Oncology and the Society of Surgical Oncology (SSO).
- An analysis of 141 patients from 17 sites in the Mayo Clinic Cancer Research Consortium demonstrated the value of using the Oncotype DX test to identify stage II colon cancer patients with low risk of recurrence. After receiving the Recurrence Score results, physician recommendations for adjuvant chemotherapy in patients with low risk of recurrence decreased by 22 percent, which resulted in direct medical care costs savings of $4,200 per patient.This is the first health economic study of the Oncotype DX Colon Cancer test conducted in clinical practice. A separate modeling study showing that the use of the Oncotype DX test in stage II colon cancer patients may lead to health care cost savings while improving clinical outcomes was recently published in the December 2012 issue of Value of Health. Abstract #391: "Real-world comparative economics of a 12-gene assay for prognosis in stage II colon cancer" will be presented on Saturday, January 26, from 7:00–7:55 a.m. Pacific Time at Moscone West, San Francisco, Calif.