Pacira Pharmaceuticals, Inc. (NASDAQ: PCRX) today announced that the full findings from the regional health system analysis conducted by Barnabas Health to quantify the relationship between opioid use, total hospital charges and patient length of stay (LOS) were published in Hospital Pharmacy. This study demonstrated that in addition to increased hospital charges, patients undergoing total abdominal hysterectomy (TAH) with an unusually long LOS (five days or more) also had a higher incidence of opioid-related adverse events (ORAEs) compared to the control group of patients with a more typical LOS (less than five days). Preliminary findings from this retrospective analysis were discussed in a poster presentation given at the American Society of Health-System Pharmacists meeting in December 2011. “In numerous published studies, including this analysis, higher opioid use has been associated with opioid-related adverse events, prolonged hospitalization and increased costs of care,” said Dave Stack, President and CEO of Pacira. “Reliance on an opioid-based pain management regimen can not only have a negative impact on a patient’s recovery course, but can also increase the overall cost burden on the healthcare system.” In the study, medical records of patients undergoing TAH were reviewed to identify LOS ‘outliers,’ or patients with an LOS lasting greater than or equal to five days. Researchers matched 97 LOS outliers with an equal number of control patients who had an LOS that was less than five days, and similar baseline characteristics. Comparisons between the two groups showed that LOS outliers:
- Remained hospitalized 5.5 days longer than controls
- Had $8,544 more in total hospital charges than control patients ($14,289 vs. $5,745, respectively)
- Received more than two times the total opioid dose compared to the controls by the time of discharge
- Reported a markedly higher incidence of ORAEs compared to controls
- Gastrointestinal ORAEs occurred in 44 percent of outliers compared to 19 percent of control patients; P< 0.01
- Respiratory ORAEs occurred in 12 percent of outliers compared to just one percent of control patients; P< 0.01
Please see the full Prescribing Information for more details available at www.EXPAREL.com.1. The Joint Commission. Sentinel Event Alert: Safe Use of Opioids in Hospitals. 2012; issue 49.