Fast forward to 2012. Under Coles' leadership, Onyx is now a three-drug company. The multiple myeloma drug Kyprolis received FDA approval in July. Stivarga, a new treatment for colon cancer, was approved in September. Coles had a lot to do with both of the new drugs. Kyprolis came to Onyx through the October 2009 acquisition of Proteolix (a deal that some investors disliked when it was announced.) At one time, Bayer tried to claim 100% ownership of Stivarga but an Onyx lawsuit and tough negotiating on Coles' part helped the keep its ownership stake. Onyx is no longer the weak spouse in its marriage to Bayer. Onyx shares are up more than 70% this year, buoyed by the two new drug approvals and the strong commercial launch of Kyprolis. John Martin, Gilead Sciences: This is where I need to take some lumps. Martin was a finalist for the worst biotech CEO of 2011. I wrote up his nomination days before Gilead announced the $11 billion purchase of Pharmasset last December. I could have removed Martin from the list, but didn't. Here's what I wrote: Looming patent expirations on key Gilead HIV drugs have weighed heavily on the company's stock price. Martin deserves credit for building Gilead into the dominant HIV drug company but he's also at fault for letting that coveted franchise stagnate. Multiple acquisitions and partnerships in other disease areas have proven to be expensive failures. Most glaringly, Gilead's efforts to develop its own Hep C drugs have gone nowhere, a corporate embarrassment given Gilead's supposed antiviral drug expertise. Everyone can agree that Gilead needed to do something to reinvigorate growth. But is gambling $11 billion on a risky Pharmasset acquisition the best idea Martin could come up with? Right now, the deal smacks of desperation, which is enough to land Martin a spot as a worst biotech CEO nominee. Well, that "desperate" deal for Pharmasset looks a lot smarter 12 months later now that Gilead is leading the race to develop the next generation of all-oral hepatitis C regimens. Martin paid a lot for Pharmasset and its lead "nuc" sofosbuvir but at least he bought a real drug. Bristol-Myers Squibb ( INHX) paid $2.5 billion for Inhibitex and all it got in return was a toxic, failed drug and a $1.8 billion write off. The approval of the new HIV pill Stribild in August also bolstered Gilead's core business franchise. Gilead shares are up 80% year to date. Leonard Schleifer, Regeneron Pharmaceuticals: Wall Street was divided on the commercial prospects for Regeneron's Eylea when FDA approved the new therapy for a common cause of blindness in November 2011. Could Eylea make a dent in the market position held firmly by Roche and its competing drugs Lucentis and "off-label" Avastin? One year later, the answer is a resounding, yes. Under Schleifer's command (and with the help of Bayer overseas), Regeneron has engineered one of the most successful new drug launches in history. In just nine months, Eylea sales have already reached $562 million with an annual run rate close to $1 billion, well above the company's initial forecasts. With Eylea's success, Regeneron has turned a $168 million net loss in the first nine months of 2001 into a $280 million profit in the same period this year. Regeneron's stock price has more than tripled in 2012, making the company one of the most valuable and fastest growing in the biotech sector. Chris Garabedian, Sarepta Therapeutics: Garabedian is probably a controversial selection for a best CEO candidate. His co-nominees all lead companies with multiple approved drugs generating hundreds of millions, if not billions, in annual revenue. By comparison, Sarepta (formerly AVI Biopharma) hasn't accomplished much -- yet. Garabedian makes the list as a representative of all development-stage biotech CEOs who dream of taking a seat at the big boy-biotech table. But this is no charity selection because Sarepta's year has been nothing short of phenomenal. Being the best-performing bio-pharma stock in 2012 is fantastic, but more importantly, results from the small eteplirsen study presented this year have provided real hope to Duchenne muscular dystrophy patients and their families. A profoundly positive treatment for the rare and relentlessly degenerative neuromuscular disorder appears on the way. Before we get to the voting, let's discuss the biotech CEOs who did well this year but fell just short of making the cut this year. Arena Pharmaceuticals' ( ARNA) Jack Lief was a contender but better to see how Belviq launches next year before anointing him. The same came be said for Pharmacyclics' ( PCYC) Robert Duggan and Ariad Pharmaceuticals' ( ARIA) Harvey Berger -- both are strong contenders for next year's award if their respective cancer drugs fulfill their potential. Medivation's ( MDVN) David Hung had great year with the approval of the prostate cancer drug Xtandi but he was nominated in 2011. BioMarin's ( BMRN) Jean-Jacques "JJ" Beinaim is always a class act. Now, it's your turn to decide which biotech CEO was 2012's best. Please vote in the poll below.