- Title: Clinical safety and activity in a Phase 1 trial of IPI-145, a potent inhibitor of phosphoinositide-3-kinase (PI3K)-delta,gamma in patients with advanced hematologic malignancies (Abstract #3663)
- Time: 10:00 a.m. – 8:00 p.m. ET (viewing) and 6:00 p.m. – 8:00 p.m. (presentation)
- Presenter: Ian W. Flinn, M.D., Ph.D., Director, Hematologic Malignancies Research Program, Sarah Cannon Research Institute
- Location: Georgia World Congress Center, Hall B1-B2.
Responses were observed at each of the lowest dose levels of IPI-145 evaluated, including 8 mg BID, 15 mg BID and 25 mg BID, in patients with chronic lymphocytic leukemia (2 partial responses in 3 patients), indolent non-Hodgkin’s lymphoma (1 complete response in 2 patients) and mantle cell lymphoma (1 partial response in 1 patient), for a total of 4 responses among 6 evaluable patients with either chronic lymphocytic leukemia, indolent non-Hodgkin’s lymphoma or mantle cell lymphoma. Responses were not observed among five evaluable patients with aggressive non-Hodgkin’s lymphoma or multiple myeloma.The Phase 1 trial is evaluating patients with B-cell and T-cell malignancies in the ongoing dose escalation. About Infinity Pharmaceuticals, Inc. Infinity is an innovative drug discovery and development company seeking to discover, develop and deliver to patients best-in-class medicines for diseases with significant unmet need. Infinity combines proven scientific expertise with a passion for developing novel small molecule drugs that target emerging disease pathways. Infinity’s programs focused on the inhibition of phosphoinositide-3-kinase and heat shock protein 90 are evidence of its innovative approach to drug discovery and development. For more information on Infinity, please refer to the company’s website at www.infi.com. Forward-Looking Statements This press release contains forward-looking statements within the meaning of The Private Securities Litigation Reform Act of 1995. Such forward-looking statements include those regarding the expected timing for reporting data regarding IPI-145, the therapeutic potential of IPI-145 and the potential for IPI-145 to be the best-in-class PI3K inhibitor in hematologic malignancies and inflammation. Such statements are subject to numerous important factors, risks and uncertainties that may cause actual events or results to differ materially from the company’s current expectations. For example, there can be no guarantee that Infinity will report data in the timeframes it has estimated, that any product candidate Infinity is developing will successfully complete necessary preclinical and clinical development phases or that development of any of Infinity’s product candidates will continue. Further, there can be no guarantee that any positive developments in Infinity’s product portfolio will result in stock price appreciation. Management’s expectations could also be affected by risks and uncertainties relating to: Infinity’s results of clinical trials and preclinical studies, including subsequent analysis of existing data and new data received from ongoing and future studies; the content and timing of decisions made by the U.S. FDA and other regulatory authorities, investigational review boards at clinical trial sites and publication review bodies; Infinity’s ability to enroll patients in its clinical trials; unplanned cash requirements and expenditures; development of agents by Infinity’s competitors for diseases in which Infinity is currently developing its product candidates; and Infinity’s ability to obtain, maintain and enforce patent and other intellectual property protection for any product candidates it is developing. These and other risks which may impact management’s expectations are described in greater detail under the caption “Risk Factors” included in Infinity’s Annual Report on Form 10-K for the year ended December 31, 2011 and subsequent filings filed by Infinity with the Securities and Exchange Commission. Any forward-looking statements contained in this press release speak only as of the date hereof, and Infinity expressly disclaims any obligation to update any forward-looking statements, whether as a result of new information, future events or otherwise.