The Boston Globe once again turns its spotlight on the region’s best employers in its Top Places to Work magazine, which will appear in The Boston Sunday Globe on November 4. This year, Millennium, the Analysis Group and the Boston Harbor Hotel won the highest marks, with Globoforce topping the magazine’s new small business category for organizations with 50 to 99 employees. The issue will also be featured on BostonGlobe.com and Boston.com. This is the popular 44-page magazine’s fifth year of honoring the state’s most beloved workplaces based on surveys of the people who know best -- the employees themselves. “When we launched in 2008 during the Great Recession, we wondered if employers would lose focus on keeping their employees happy,” Boston Globe Business Editor Shirley Leung said. “But businesses have continued to make strides in employee appreciation and opportunities. With more than 300 companies surveyed this year, we saw our highest participation rate to date.” Millennium: The Takeda Oncology Co., with about 1,200 employees in Cambridge, ranks number one in the largest employer category. Owned by Japan’s Takeda Pharmaceutical Co., Millennium retains workers by valuing collaboration and cross-cultural sensitivity. Analysis Group, number one in the large category, provides employees with plenty of mentoring and opportunities to further their studies. The Boston consultancy, with about 275 employees, provides economic analysis and expert testimony to law firms. The Boston Harbor Hotel topped the medium category for treating its roughly 200 Boston employees as well as it treats its VIP guests. The five-star property rewards employees who go above-and-beyond in customer service. Globoforce, the number one small employer, extends its product to its own workforce. The Southborough firm not only manages workplace appreciation programs for other companies but also utilizes the same rewards program to boost its own morale.