NEW YORK ( TheStreet) -- U.S. stock futures signaled a lower Wall Street open on Wednesday as skittish investors awaited the U.S. jobs report on Friday. European stocks were trading lower while Asian stocks finished mixed. Japan's Nikkei 225 index fell 0.5% to close at 8,746.87. The economic calendar in the U.S. Wednesday includes the employment change report for September from Automatic Data Processing at 8:15 a.m. EDT and the Institute of Supply Management services index for September at 10 a.m. U.S. stocks on Tuesday booked another mixed finish as investors awaited clarity on the timeline for a potential request for bailout funds from Spain. The Dow Jones Industrial Average fell 33 points, or 0.24%, to close at 13,482. Best Buy ( BBY) founder Richard Schulze and at least four private-equity firms have started examining the books of the company, the world's biggest consumer electronics chain, in what could become a potential $11 billion buyout, according to people familiar with the matter, Reuters reported. Hewlett-Packard ( HPQ) CEO Meg Whitman holds her first analyst meeting Wednesday since taking over as CEO in September 2011. Family Dollar Stores ( FDO) and Monsanto ( MON) are two of the biggies on Wednesday's earnings calendar. President Obama and Republican nominee Mitt Romney face off Wednesday evening in Denver in the first of three scheduled debates. The U.S. economy is likely to be the hottest topic of discussion. -- Written by Joseph Woelfel >To contact the writer of this article, click here: Joseph Woelfel >To submit a news tip, send an email to: firstname.lastname@example.org.