Cubist Pharmaceuticals, Inc. (NASDAQ: CBST) today provided an overview of selected studies that will be presented at the 52 nd Annual Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC) taking place from September 9 th to 12 th in San Francisco. The studies focus on the company’s lead investigational antibiotics, CXA-201 and CB-315, basic science research as well as the marketed antibiotic, CUBICIN® (daptomycin for injection). “The breadth of presentations at ICAAC shows how we are advancing science to not only inform the appropriate use of CUBICIN but also to discover and develop new antibiotics for serious and potentially life-threatening infections,” said Steve Gilman, PhD, Chief Scientific Officer at Cubist Pharmaceuticals. “We’re excited that our lead pipeline antibiotics are now in pivotal Phase 3 trials and we hope to one day make them available to doctors and patients who deal with the challenge of emerging resistant infections.” A list of selected presentations can be found on the company’s website. Key highlights include: CXA-201 (Ceftolozane/tazobactam) CXA-201, a novel cephalosporin in combination with tazobactam, is in development for the treatment of certain serious infections caused by multi-drug resistant (MDR) Gram-negative organisms, particularly Pseudomonas aeruginosa and those in the Enterobacteriaceae family. This year at ICAAC, six studies on CXA-201 will be presented. In one important study, CXA-201 showed greater potency than currently available anti- Pseudomonas aeruginosa cephalosporins (ceftazidime and cefepime) and piperacillin/tazobactam when tested against Pseudomonas aeruginosa and Enterobacteriaceae strains from hospitals in the United States. Activity of the Novel Antimicrobial Ceftolozane/Tazobactam Tested Against Contemporary Clinical Strains from USA Hospitals (2011) (Abstract E-199) Sunday, September 9, 2012, 11:30 a.m. - 1:30 p.m. PDT, Halls A-C. CB-315 CB-315, a novel oral antibiotic, is in development for the treatment for Clostridium difficile-associated diarrhea, or CDAD. Clostridium difficile causes diarrhea linked to 14,000 American deaths each year. This year the company initiated pivotal Phase 3 studies of CB-315, and in vitro data at ICAAC will show that Clostridium difficile is more susceptible to CB-315 than to other antibiotics like vancomycin and moxifloxacin. Susceptibilities of Clostridium difficile to CB-183,315 and Comparators (Abstract E-807) Monday, September 10, 2012, 11:15 a.m. - 1:15 p.m. PDT, Halls A-C. Discovery Biology Several abstracts on basic science and drug discovery efforts will be presented at the meeting. One of these focuses on CB-027, which is a novel broad spectrum cephalosporin with potent in vitro activities against both Gram-positive and Gram-negative bacteria. This includes methicillin-resistant Staphylococcus aureus (MRSA) and Pseudomonas aeruginosa. In this animal study, CB-027 showed potent in vivo activity against several drug-resistant strains, including MRSA, ceftazidime-resistant Pseudomonas aeruginosa and Klebsiella pneumonia. In vivo Efficacy of CB-027 against Methicillin-Resistant Staphylococcus aureus , and Ceftazidime-Resistant Pseudomonas aeruginosa and Klebsiella pneumoniae Infections in Mice (Abstract F-846) Monday, September 10, 2012, 11:15 a.m. - 1:15 p.m. PDT, Halls A-C. CUBICIN (daptomycin for injection) More than 30 scientific abstracts at ICAAC feature data on daptomycin. Importantly in an oral presentation, new data will show that early use of daptomycin significantly lowers rates of clinical failure, including both 90-day mortality and microbiological failure compared to vancomycin for infections caused by certain strains (VAN MIC > 1 mg/L) of MRSA.
Daptomycin versus Vancomycin for Methicillin-Resistant Staphylococcus aureus Bacteremia with VAN MIC > 1 mg/L: A Matched Cohort Study (Abstract K-1121) Monday, September 10, 2012, 2:45 a.m. - 3:00 p.m. PDT, Room 132.About CUBICIN CUBICIN® (daptomycin for injection) is approved in the U.S. and many other non-US markets as therapy for Staphylococcus aureus bloodstream infections (bacteremia), including right-sided endocarditis, caused by methicillin-resistant Staphylococcus aureus (MRSA) and methicillin-susceptible Staphylococcus aureus (MSSA), and complicated skin infections caused by certain Gram-positive bacteria, including MRSA. CUBICIN is not indicated for the treatment of pneumonia. Most adverse events reported in clinical trials were mild to moderate in intensity. The most common were anemia, constipation, diarrhea, nausea, vomiting, injection site reactions, and headache. To reduce the development of drug-resistant bacteria and maintain the effectiveness of CUBICIN, CUBICIN should be used only to treat or prevent infections that are proven or strongly suspected to be caused by bacteria susceptible to CUBICIN. For full prescribing information, including important safety information, please visit www.cubicin.com. About Infection-causing bacteria Bacteria are categorized in two main classes, Gram-positive and Gram-negative. This classification is based on the structure of the bacterial cell and has implications as it relates to antibiotics. Both Gram-positive and Gram-negative bacteria cause infections. Resistance to commonly-used antibiotics is becoming increasingly prevalent in both Gram-positive and Gram-negative bacteria. Gram-positive bacteria, such as Staphylococcus aureus, generally have a thick outer cell wall and a single cell membrane, whereas Gram-negative bacteria, like Pseudomonas aeruginosa, have an outer cell membrane and a thinner cell wall. Infection-causing Gram-positive bacteria include Staphylococcus aureus and Clostridium difficile. Diseases caused by these Gram-positive bacteria include infections caused by Methicillin-Resistant Staphylococcus aureus, commonly referred to as MRSA, and CDAD. Examples of infective Gram-negative bacteria include Pseudomonas aeruginosa, Escherichia coli, Klebsiella pneumoniae, and Acinetobacter baumannii. The diseases caused by Gram-negative bacteria include peritonitis (a type of abdominal infection), septicemia (blood infection), pneumonia, neonatal (newborn) meningitis, urinary tract infections, intra-abdominal infections and burn and wound infections. About Pseudomonas aeruginosa Pseudomonas aeruginosa is one of the most prevalent Gram-negative bacteria responsible for hospital-acquired infections (also known as nosocomial infections). Nosocomial infections are becoming increasingly common in intensive care units (ICU) and data from the National Nosocomial Infections Surveillance of ICUs in the United States shows that Pseudomonas aeruginosa is the most frequently isolated Gram-negative cause. Pseudomonal infections in the hospital causing pneumonia and urinary tract infections have almost doubled between 1975 and 2003. Similar increases in Pseudomonal infections were observed in Europe SENTRY Antimicrobial Surveillance Program, between 1997 and 2002. Pseudomonal infections can involve any part of the human body, but among the most common are lung urinary tract, bloodstream, wound/burn, and intra-abdominal infections. Resistance to current treatment regimens for such infections is growing, with the increasing appearance of Pseudomonas aeruginosa strains expressing multi-drug resistance against commonly used anti-pseudomonal antibiotics. About CDAD CDAD is a disease caused by an overgrowth of, and toxin production by Clostridium difficile, a Gram-positive bacterium naturally found in the lower gastrointestinal tract. This overgrowth is caused by the use of antibiotics for the treatment of common community and hospital acquired infections. Many antibiotics cure the underlying infection but, as a consequence, disrupt the natural balance of intestinal bacteria which Clostridium difficile to overgrow. The overgrown Clostridium difficile bacteria produce enterotoxin and cytotoxin, two proteins that can lead to potentially life-threatening severe diarrhea and sepsis (blood infection). CDAD rates and severity are increasing, due in part to the spread of a new strain with increased virulence and greater resistance to fluoroquinolones, a standard of care treatment. According to an article in the October 2008 issue of the New England Journal of Medicine, during the mid- and late-1990s, the reported incidence of infections caused by Clostridium difficile in acute care hospitals in the United States remained stable at 30 to 40 cases per 100,000. However in 2001, this number rose to almost 50, with subsequent increases to the point that the number of cases that were reported in 2005 (84 per 100,000) was nearly three times the 1996 rate (31 per 100,000). About Cubist Cubist Pharmaceuticals, Inc. is a biopharmaceutical company focused on the research, development, and commercialization of pharmaceutical products that address significant unmet medical needs in the acute care environment. Cubist is headquartered in Lexington, Mass. Additional information can be found at Cubist’s web site at www.cubist.com. Cubist and CUBICIN are registered trademarks of Cubist Pharmaceuticals, Inc.