Isis PharmaceuticalsIsis Pharmaceuticals ( ISIS) is engaged in antisense technology, exploiting a drug discovery platform to create a pipeline of drugs. This stock is trading up 9.1% at $14.87 in recent trading. Today's Volume: 1.6 million Average Volume: 1 million Volume % Change: 174% >>5 Stocks Poised for Big Breakouts From a technical perspective, ISIS is ripping higher here right off some near-term support at $13.50 with heavy volume. This move has pushed ISIS into breakout territory and 52-week-high territory, since the stock has taken out some past overhead resistance levels at $13.60 to $14.05. Traders should now look for long-biased trades as long as ISIS is trending above $13.60 with strong upside volume flows. I would consider any upside volume day that registers near or above 1 million shares as bullish. If ISIS can maintain that trend, then this stock has a great chance of hitting $20 in the near future.