A reconciliation of Adjusted EBITDA from continuing operations to net loss from continuing operations, is presented in the table titled, “Unaudited Non-GAAP Financial Information – Adjusted EBITDA,” included on page 3.

Total Revenue

For the second quarter of 2012, revenue increased by 6% to $288.0 million from $270.6 million for the second quarter of 2011. For the first half of 2012, revenue increased by 11% to $576.4 million from $517.7 million for the first half of 2011.

Three Months Ended June 30
   

Six Months Ended June 30

2011

US$m
 

2012

US$m
     

2011

US$m
 

2012

US$m
  Product revenue  
183.1 211.5 Tysabri – U.S. 353.0 412.5
86.2 76.9 Tysabri – ROW 161.5 164.1
269.3 288.4 Total Tysabri 514.5 576.6
0.7 Maxipime 0.7
0.4 (0.5) Azactam 0.4 (0.5)
0.2 0.1 Royalties 2.1 0.3
270.6 288.0 Total revenue 517.7 576.4

Tysabri

Global in-market net sales of Tysabri can be analyzed as follows:

Three Months Ended June 30
   

Six Months Ended June 30

2011

US$m
 

2012

US$m

 
     

2011

US$m
 

2012

US$m
183.1   211.5 United States 353.0   412.5
205.9 184.0 ROW 385.4 382.0
389.0 395.5 Total Tysabri in-market net sales 738.4 794.5

At the end of June 2012, approximately 69,100 patients were on therapy worldwide, including approximately 31,900 commercial patients in the United States and approximately 36,400 commercial patients in the ROW, representing a 4% increase over the approximately 66,700 patients (revised) who were on therapy at the end of March 2012, and 13% over the approximately 61,200 patients (revised) who were on therapy at the end of June 2011.

If you liked this article you might like

Experimental Tau Protein Drug Tangled Up in Late-Stage Alzheimer's Study Failure

With Martin Shkreli Long Gone, Retrophin is an 'Interesting Opportunity'

Despite Shkreli Drama, Retrophin Looks Interesting Now

Celtic Tiger Tries to Roar Again

Cramer's 6 Stocks in 60 Seconds: PRGO CREE HOG GME ORCL MHK (Update 1)