- Mean total hospitalization costs increased by $7,949 and $12,724 for patients experiencing an ORADE after a laparoscopic or open GI procedure, respectively.
- Mean LOS was 1.5-1.9 times and 1.3-2.0 times longer for patients experiencing an ORADE after a laparoscopic or open GI procedure, respectively.
In this analysis, researchers utilized the Premier healthcare alliance’s database—the nation's most comprehensive repository of clinical, financial and outcomes information—to identify adult patients who received opioids after undergoing laparoscopic or open colectomy or cholecystectomy procedures from 2008 to 2010. One in 10 patients included in the study experienced ileus, which can tremendously impact patient recovery.This analysis, also supported by Pacira Pharmaceuticals, demonstrated that higher opioid doses were associated with higher incidence of ileus. In each surgical group, total opioid consumption (converted to the morphine-equivalent dose [MED]) that exceeded the median MED was associated with significantly increased total hospitalization costs, LOS, and 30-day readmission rates, even for patients undergoing laparoscopic procedures, where the incidence of ileus is typically less common. For the total population of patients experiencing ileus compared to those who did not:
- Mean total hospitalization costs increased by $15,928 ($31,374 vs $15,446, respectively; P<0.0001)
- Mean LOS increased by 7.3 days (13.6 days vs 6.3 days, respectively; P<0.0001)
- Thirty-day readmission rates were approximately 6% higher (16.1% vs 10.2%, respectively; P<0.0001)