- When dosed weekly (at 55 mg/m 2), 33% (7/21) of patients had an objective response (a complete response/CR or partial response/PR).
- When the same dose level was administered with this modified schedule, 29% (6/21) of patients had an objective response and another 43% (9/21) had stable disease.
About SAR3419SAR3419 is an investigational TAP compound that consists of a CD19-binding antibody developed by ImmunoGen with one of the Company’s potent cell-killing agents, DM4, attached using one of its engineered linkers. The antibody enables the compound to bind specifically to cancer cells expressing its CD19 target and the DM4 serves to kill these cells. About ImmunoGen, Inc. ImmunoGen, Inc. develops targeted anticancer therapeutics using the Company's expertise in tumor biology, monoclonal antibodies, potent cancer-cell killing agents and engineered linkers. The Company's TAP technology uses monoclonal antibodies to deliver one of ImmunoGen's proprietary cancer-cell killing agents specifically to tumor cells. There are now numerous TAP compounds in clinical development with a wealth of clinical data reported. ImmunoGen's collaborative partners include Amgen, Bayer HealthCare, Biotest, Lilly, Novartis, Roche and Sanofi. The most advanced compound using ImmunoGen's TAP technology, trastuzumab emtansine (T-DM1), is in Phase III testing through the Company's collaboration with Genentech, a member of the Roche Group. More information about ImmunoGen can be found at www.immunogen.com. 1Younes, A. et al., ASH, Dec. 2009 2Coiffer B. et al., 11 th International conference on Malignant Lymphoma, June 2011 Rituxan ® is a registered trademark of Biogen Idec. This press release includes forward-looking statements. For these statements, ImmunoGen claims the protection of the safe harbor for forward-looking statements provided by the Private Securities Litigation Reform Act of 1995. It should be noted that there are risks and uncertainties related to the development of novel anticancer products, including SAR3419, including risks related to clinical studies and their results. A review of these risks can be found in ImmunoGen's Annual Report on Form 10-K for the fiscal year ended June 30, 2011 and other reports filed with the Securities and Exchange Commission.