About the Dynamic Polyconjugate siRNA Delivery PlatformAchieving safe and effective in vivo delivery of siRNA to the appropriate tissue and cell type is the primary barrier to development of RNAi as a therapeutic modality. Dynamic PolyConjugate (DPC) technology overcomes this barrier. Key features of the DPC technology include:
- New classes of membrane-active and biodegradable polymers,
- Reversible chemical masking of the polymers so that membrane-lytic activity is revealed only in the acidic environment of endosomes, and
- The ability to attach ligands to guide the polymer and the siRNA cargo to specific cell types in vivo.