Additional fMRI Study DetailsThe fMRI data, which were presented in multiple sessions, come from an exploratory double-blind crossover study of 17 women who were given either Lyrica (150-450 mg/day) or a placebo for 14 days, then, after a washout period, crossed over to the opposite group. Before and after each treatment period, functional MRI images were taken while the patients received blunt pressure pain to measure activity in the brain. Pfizer previously reported other results from this study which showed that Lyrica reduced glutamate in fibromyalgia patients in areas of the CNS associated with pain processing. “These data demonstrate Pfizer’s commitment to enhancing the scientific community’s understanding of Lyrica,” said Steven J. Romano, M.D., senior vice president, Head, Medicines Development Group, Global Primary Care Business Unit, Pfizer, Inc. “By using technologies such as fMRI, we can contribute to a growing body of research in pain physiology with the goal of answering patient needs in a more meaningful way.” About Lyrica Lyrica ® is currently approved in 110 countries and regions globally. In the United States, Lyrica (pregabalin) capsules CV are indicated for neuropathic pain associated with diabetic nerve pain, post herpetic neuralgia (pain after shingles), fibromyalgia and partial onset seizures in adults with epilepsy who take one or more drugs for seizures. Antiepileptic drugs (AEDs) including Lyrica increase the risk of suicidal thoughts or behavior in patients taking AEDs for any indication. There have been post-marketing reports of angioedema and hypersensitivity with Lyrica. Treatment with Lyrica may cause dizziness, somnolence, dry mouth, edema and blurred vision. Other most common adverse reactions include weight gain, constipation, euphoric mood, balance disorder, increased appetite and thinking abnormal (primarily difficulty with concentration/attention.) For Lyrica prescribing information, please visit www.lyrica.com. Pfizer Inc.: Working together for a healthier world® At Pfizer, we apply science and our global resources to improve health and well-being at every stage of life. We strive to set the standard for quality, safety and value in the discovery, development and manufacturing of medicines for people and animals. Our diversified global health care portfolio includes human and animal biologic and small molecule medicines and vaccines, as well as nutritional products and many of the world’s best-known consumer products. Every day, Pfizer colleagues work across developed and emerging markets to advance wellness, prevention, treatments and cures that challenge the most feared diseases of our time. Consistent with our responsibility as the world’s leading biopharmaceutical company, we also collaborate with health care providers, governments and local communities to support and expand access to reliable, affordable health care around the world. For more than 150 years, Pfizer has worked to make a difference for all who rely on us. To learn more about our commitments, please visit us at www.pfizer.com.