One under-$10 name that's starting to set up for a big breakout trade is Trius Therapeutics ( TSRX), a biopharmaceutical company focused on the discovery, development and commercialization of antibiotics for life threatening infections. This stock is off to a weak start in 2012, with shares off by around 25%. If you take a look at the chart for Trius Therapeutics, you'll notice that this stock has been downtrending since last December, from a high of $8 to a recent low of $4.71 a share. During that downtrend, this stock consistently made lower highs and lower lows, which is bearish price action. That said, now the stock has started to make higher lows for the last month, and it's moving within range of triggering a near-term breakout. >>5 Breakout Stocks to Trade for Gains Market players should now look for long-biased trades in TSRX if this stock can manage to break out above some near-term overhead resistance at $5.42 a share with high-volume. Look for volume on that move that hits near or well above its three-month average volume of 270,649 shares. If TSRX can sustain a move and close over $5.42 a share, then it will also mean the stock has pushed back above a significant downtrend line that starts at around $5.85 a share. This could signal that a significant trend change is underway for TSRX from bearish to bullish. If we can get a close with high-volume over $5.42, then this stock could easily be setting up to a make a run move back towards its 200-day moving average of $6.48 a share or possibly higher into the mid-7s. I would probably use some near-term support at $5 as a good reference point for a mental stop. If $5.42 is taken out, then watch for the stock to move above some more near-term resistant at $5.74 to $5.86 to increase the probability of that move to $6.48 or higher.