Agenus ( AGEN) is a biotechnology company focused on the development and commercialization of technologies to treat cancers and infectious diseases, based on immunological approaches. This stock is trading up 5.3% to $6.28 in recent trading. Today's Range: $6.12-$6.60 52-Week Range: $1.92-$6.72 Volume: 583,000 Three-Month Average Volume: 220,406 From a technical perspective, AGEN is spiking higher on heavy volume, and its quickly approaching a major breakout trade. That breakout will hit once AGEN can manage to take out some past overhead resistance levels at $6.72 to $6.96 with volume. Traders should now look for long-biased trades if AGEN can sustain a move and close above those levels on volume that's near or well above 220,406 shares. If we get that action soon, look for AGEN to make a run at its next major overhead resistance levels at $8.88 to $10.32 in the near future. To see more stocks under-$10 that are making notable moves higher today, check out the Stocks Under-$10 Moving Higher portfolio on Stockpickr. -- Written by Roberto Pedone in Winderemere, Fla.