Idera Pharmaceuticals (Nasdaq: IDRA) today announced that Nicola La Monica, Ph.D., Vice President of Biology at Idera, will present at the Cancer Immunotherapy Summit on February 28, 2012, at 2:30 pm ET in Boston, MA. Dr. La Monica, in an oral presentation entitled “TLR Modulation for Immunotherapy of Cancer”, will provide an overview of Idera’s oncology program using agonists of Toll-like receptors (TLRs). Idera’s TLR agonist candidates modulate receptor-mediated immune responses and are being studied as immune modifiers in the potential therapy of cancer. Idera has developed a portfolio of TLR agonists for the treatment of various cancer indications both in combination with targeted agents as well as for use as vaccine adjuvants. Idera’s portfolio includes:
- IMO-2055, a TLR9 agonist – Idera recently announced positive from a Phase 1b results of IMO-2055 in combination with Tarceva® and Avastin® in patients with advanced non-small cell lung cancer. Results from a Phase 2 study of IMO-2055 in combination with Erbitux® for the treatment of squamous cell cancer of the head and neck are expected in the second quarter of 2012
- TLR 7,8 and 9 agonists – Idera recently announced that Merck has selected several novel TLR agonists targeted to TLR7, TLR8 or TLR9 for evaluation and use as vaccine adjuvant candidates under the companies' collaboration and license agreement
- IMO-4200 – Idera-4200 is a dual agonist of TLR7 and 8. Idera has conducted preclinical studies of IMO-4200 for hematological malignancies
- TLR3 agonists – Idera has identified novel TLR3 agonists for potential use as adjuvants in combination with cancer vaccines
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