A stock in the biotechnology and drugs complex that's nearing a big breakout is Halozyme Therapeutics ( HALO), a biopharmaceutical company developing and commercializing products targeting the extracellular matrix for the diabetes, cancer, dermatology and drug delivery markets. This stock is out the gate strong in 2102, with shares up over 11%. If you look at the chart for Halozyme Therapeutics, you'll see that stock has been uptrending strong since it found big buying support back in October at around $5.60 a share. During the recent uptrend, this stock has been consistently making higher lows and higher highs, which is bullish price action. Now the stock is rapidly approaching a big breakout if it can manage to clear some near-term overhead resistance. Market players should put HALO on their trading radar for a sustained high-volume move and close above $10.88 to $11 a share. Look for volume that registers near or above its three-month average action of 633,324 shares. At last check, HALO hit $11 a share today and the volume is just 100,000 shares short of that average action. I would consider any high-volume move over $10.88 to $11 a share to be very bullish since it will push HALO into all-time high territory. Momentum money could easily pile into this stock off a high-volume close over $11. You could simply be a buyer of HALO once it closes over $10.88 to $11 a share with volume. I would simply use a mental stop that's a few percentage points below $10.88 in case the breakout fails. You could also use a stop a bit lower near some previous support at $10.05. I am looking for a sizeable spike higher by 10% or more if this stock can enter all-time high territory with strong volume. I also featured Halozyme earlier this month in " 5 Stocks Hitting New 52-Week Highs."