Idera Pharmaceuticals (Nasdaq: IDRA) today announced that it presented new data showing that IMO-4200, a dual agonist of Toll-like receptor (TLR) 7 and TLR8, in combination with approved cancer treatments increased antitumor activity in preclinical models of lymphoma. The presentation by Idera scientists, entitled “IMO-4200, a novel TLR7 and TLR8 dual agonist, enhances antitumor effect of ofatumumab, rituximab and cytotoxics in preclinical models of hematological malignancies”, abstract number 3724, was made at the 53 rd annual meeting of the American Society for Hematology being held in San Diego, California December 11-13, 2011.

“The data presented show that IMO-4200 provides a novel scientific rationale for the targeted immunotherapy of hematological malignancies,” said Nicola La Monica, Ph.D., VP of Biology of Idera Pharmaceuticals. “IMO-4200 has shown to potentiate the anti-cancer activity of a broad range of approved agents, including rituximab, bortezomib and ofatumumab, in preclinical models of lymphoma.”

In the data presented today, IMO-4200 was evaluated in preclinical cell-based assays and in combination with approved cancer therapy agents in mouse models of lymphoma.
  • IMO-4200 in combination with ofatumumab, an anti-CD20 antibody, resulted in:
    • improved antitumor activity
    • increased survival compared to treatment with either agent alone
    • enhancement of complement-dependent cytotoxicity, a mechanism by which ofatumumab exerts its antitumor effect
  • IMO-4200 in combination with rituximab, an anti-CD20 antibody, and fludarabine or IMO-4200 in combination with rituximab and bendamustine resulted in:
    • improved antitumor activity
    • increased survival
    • enhanced clearance of circulating tumor cells
    • greater antibody-dependent cell cytotoxicity, a mechanism by which rituximab exerts its effect

Authors of the presentation were Daqing Wang, Ph.D., Melissa Precopio, Ph.D., Michael J. Reardon, Ph.D., Tao Lan Ph.D., Jimmy X. Tang, Ekambar R. Kandimalla, Ph.D., Alice Bexon M.D., Nicola La Monica, Ph.D. and Sudhir Agrawal, D. Phil.

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