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NEW YORK ( TheStreet) -- Isis Pharmaceuticals (Nasdaq: ISIS) hit a new 52-week low Monday as it is currently trading at $6.53, below its previous 52-week low of $6.55 with 332,765 shares traded as of 12:50 p.m. ET. Average volume has been 685,200 shares over the past 30 days. Isis has a market cap of $679.4 million and is part of the health care sector and drugs industry. Shares are down 33% year to date as of the close of trading on Friday. Isis Pharmaceuticals, Inc. engages in the discovery and development of antisense drugs using antisense drug discovery platform. The company's antisense drug development programs focus on treating cardiovascular, metabolic, cancer, and severe neurodegenerative diseases.