AstraZeneca Sinks on Crestor Trial

BOSTON ( TheStreet) -- AstraZeneca's ( AZN) hopes of differentiating its anti-cholesterol drug from the top-selling Lipitor have been dashed.

AstraZeneca said its Crestor anti-cholesterol medicine failed to beat Pfizer's ( PFE) Lipitor in a head-to-head clinical trial, dubbed Saturn. AstraZeneca had hoped the trial would differentiate Crestor and eat into Lipitor's $12 billion in sales.

While the Saturn trial showed Crestor had a "numerically greater" reduction in artery-clogging plaque in patients compared to Lipitor, the results were not statistically significant.

A secondary measure did show Crestor had a statistical significance over Lipitor, AstraZeneca said.

AstraZeneca shares trading in London were down nearly 3%.

-- Written by Robert Holmes in Boston.

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