Our current research activity for the Sweet Taste Program include continuing work on new sucrose enhancers that have distinct physical properties which may be advantageous for a broad range of beverages and other product applications. We are assessing a number of very interesting new sucrose enhancers that have significant enhancement activity along with desirable taste and initial safety profile. These activities could lead to a selection for development later this year.

We are also having an ongoing effort to discover and develop new flavor ingredients that amplifies the sweet taste of fructose, a key component of high fructose corn syrup. We have identified enhancers that demonstrated activity in Senomyx's proprietary fructose screening assays. Optimization of these enhancers, further screening, and taste tests are ongoing.

As we discussed previously, Senomyx's activities to discover and develop natural high-potency sweeteners are an important new focus for the Sweet Taste Program. We have expanded our natural products library and high-throughput screening of the library has begun. The screening is proceeding well and we have already identified several plant-derived samples from the library that have significant activity in the assay. Current activities include preparing these plant extract samples for in-house taste tests.

I would also like to draw attention to impressive breakthroughs in our Cooling Flavors Program. The goal of this program is to identify novel cooling flavors that do not have the limitations of currently available agents. We have now identified new cooling flavors that mimics the time-intensity profile of agents that have rapid onset and short acting cooling effects, as well as agents with slow onset and longer acting cooling effects.

Many of our lead Cooling Flavor candidates have demonstrated approximately tenfold greater potency than a commonly used agent in taste tests. These new cooling flavors are currently being evaluated in a variety of product prototypes by Senomyx and Firmenich, our partner for this program, which could lead to a decision to begin development activities.

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