First Interstate BancSystem, Inc. (NASDAQ:FIBK), will make a presentation to analysts and investors attending the Sandler O’Neill 2011 West Coast Financial Services Conference in Marina del Rey, California on Tuesday, March 8, 2011 at 1:45 p.m. MST (12:45 p.m. PST).

Lyle R. Knight, President and CEO, will participate in a panel discussion and field questions for the company. The presentation will be available through a live webcast and can be accessed at http://www.fibk.com. The presentation will also be available via audio conference by calling 877-253-8059 (use passcode: 1079263715#).

First Interstate BancSystem, Inc. is a financial services holding company, headquartered in Billings, Montana, with $7.5 billion in assets as of December 31, 2010. It is the parent company of First Interstate Bank, a community bank operating 72 offices throughout Montana, Wyoming and western South Dakota. As a recognized leader in community banking services with 23 consecutive years of profitability, First Interstate remains a family business whose culture is driven by strong family and corporate values, as well as a commitment to long-term organic growth, exemplary customer service, exceeding customer expectations through its products and services and supporting with leadership and resources, the communities it serves.

First Interstate BancSystem, Inc., Marcy Mutch, Investor Relations, +1-406-255-5322, investor.relations@fib.com, 401 North 31st Street, Billings, Montana 59116

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