Net loss from continuing operations during the fourth quarter of 2010 was $(1.4 million), or ($0.18) per share, compared to $(2.2 million), or ($0.29) per share in the fourth quarter of 2009. The decrease for the periods presented was due primarily to an increase in other income of $489,000 recognized in the fourth quarter of 2010 as well as a decrease in interest expense as a result of retiring the company's secured convertible debenture during the first quarter of 2010. Net loss from continuing operations for 2010 was $(5.9 million), or ($0.77) per share, compared to $(11.4 million), or ($1.60) per share, for 2009.

Cash and cash equivalents totaled $6.6 million as of December 31, 2010, compared to $5.4 million as of December 31, 2009. Net cash flows (used in) provided by operating activities were $(1.3 million) and $9.7 million for the three and twelve months ended December 31, 2010, respectively, compared to $(2.4 million) and $(10.6 million) for the three and twelve months ended December 31, 2009, respectively. The improvement in cash flows for the periods presented was due primarily to the receipt of $19.4 million in net proceeds from the settlement between CombiMatrix and National Union, which occurred during the first quarter of 2010. Also contributing to the improvement was the restructuring plan executed earlier in 2010, whereby the former Custom Array operations in Mukilteo, Washington were shut down.

Conference Call

CombiMatrix will host a conference call at 1:30 p.m. Pacific Time (4:30 p.m. Eastern) today to discuss the fourth quarter 2010 financial results. To attend the presentation by phone, dial 1-888-857-6929 for domestic callers and 1-719-457-2647 for direct dial or international callers.  To listen to the call via CombiMatrix's website, go to , in the Investor/Events section, ( A replay of the presentation will be available for 14 days, either via the CombiMatrix website Investor/Events section ( ) or by dialing 1-877-870-5176 for domestic callers or 1-858-384-5517 for direct dial international callers. When prompted, enter playback pin number 3689027. The call will also be webcast live and can be accessed at CombiMatrix's website at , in the Investor/Events section, ( ).

About CombiMatrix Corporation

CombiMatrix Corporation, through its wholly owned subsidiary, CombiMatrix Diagnostics ("CMDX"), is a CAP/CLIA certified molecular diagnostics laboratory offering comprehensive profiling of chromosomes and genes for both oncology and pre- and postnatal developmental disorders in children. CMDX offers a comprehensive and proprietary analysis of cancer tumors at the DNA, or molecular level. The Company was the first clinical laboratory in the United States to make comprehensive DNA-based genomic analysis of solid tumors, including breast, colon, lung, prostate and brain tumors, available to all oncology patients and medical professionals. The Company also offers pre- and postnatal testing services for the detection of abnormalities of genes at the DNA level beyond what can be identified through traditional technologies such as ultrasound examinations and amniocentesis. Additional information about CombiMatrix Corporation is available at . Additional information about CMDX is available at or by calling 1-800-710-0624.

Safe Harbor Statement under the Private Securities Litigation Reform Act of 1995

This press release contains forward-looking statements within the meaning of the "safe harbor" provisions of the Private Securities Litigation Reform Act of 1995. These statements are based upon our current expectations, speak only as of the date hereof and are subject to change. All statements, other than statements of historical fact included in this press release, are forward-looking statements. Forward-looking statements can often be identified by words such as "anticipates," "expects," "intends," "plans," "predicts," "believes," "seeks," "estimates," "may," "will," "should," "would," "could," "potential," "continue," "ongoing," similar expressions, and variations or negatives of these words and include, but are not limited to, statements regarding projected results of operations and management's future strategic plans. These forward-looking statements are not guarantees of future results and are subject to risks, uncertainties and assumptions that could cause our actual results to differ materially and adversely from those expressed in any forward-looking statement. The risks and uncertainties referred to above include, but are not limited to: our ability to successfully implement our strategic and operational restructuring plan; our ability to successfully expand the base of our customers and strategic partners, add to the menu of our diagnostic tests in both of our primary markets, introduce new technologies and reports, optimize the reimbursements received for our testing services, and increase operating margins by improving overall productivity and expanding sales volumes; our ability to attract and retain a qualified sales force; our ability to successfully develop products; rapid technological change in our markets; changes in demand for our future products; legislative, regulatory and competitive developments; general economic conditions; and various other factors. Further information on potential factors that could affect our financial results is included in our Annual Report on Form 10-K, Quarterly Reports of Form 10-Q, and in other filings with the Securities and Exchange Commission. We undertake no obligation to revise or update publicly any forward-looking statements for any reason, except as required by law.
COMBIMATRIX CORPORATION CONSOLIDATED SUMMARY FINANCIAL INFORMATION (In thousands, except share and per share information) (Unaudited)
  For the Three Months Ended December 31, For the Years Ended December 31,
  2010 2009 2010 2009
Services  $ 791  $ 575  $ 3,283  $ 2,335
Products  13  62  271  238
Total revenues  804  637  3,554  2,573
Operating expenses:        
Cost of services  511  274  1,931  1,354
Cost of products  5  26  253  144
Research and development expenses  334  743  2,033  2,789
Marketing, general and administrative expenses  1,790  1,376  7,667  6,536
Patent amortization and royalties  33  81  190  275
Equity in loss of investee  --  --  --  618
Goodwill impairment  --  --  16,918  --
Total operating expenses  2,673  2,500  28,992  11,716
Operating loss  (1,869)  (1,863)  (25,438)  (9,143)
Other income (expenses):        
Qualified Therapeutic Discovery Program income  489  --  489  --
Litigation settlement gain  --  --  19,385  --
Loss from early extinguishment of debt  --  --  (572)  --
Interest income  1  2  7  19
Interest expense  (5)  (557)  (361)  (2,110)
Derivatives gains (charges)  --   244  605  (163)
Total other income (expense)  485  (311)  19,553  (2,254)
Net loss from continuing operations  (1,384)  (2,174)  (5,885)  (11,397)
Loss from discontinued operations  (108)  (1,399)  (7,229)  (6,240)
Net loss  $ (1,492)  $ (3,573)  $ (13,114)  $ (17,637)
Basic and diluted net loss per share        
from continuing operations  $ (0.18)  $ (0.29)  $ (0.77)  $ (1.60)
Basic and diluted net loss per share        
from discontinued operations  (0.01)  (0.18)  (0.95)  (0.88)
Basic and diluted net loss per share  $ (0.19)  $ (0.47)  $ (1.72)  $ (2.48)
Basic and diluted weighted average        
common shares outstanding  7,620,398  7,571,178  7,612,477  7,131,371
   December 31, December 31,
  2010 2009
Total cash and cash equivalents $6,556 $5,443
Total assets $9,587 $29,100
Total liabilities $1,371 $10,581
Total shareholders' equity $8,216 $18,519
CONTACT: R. Judd Jessup         President & CEO, CombiMatrix Corporation         Tel (949) 753-0624                  Investor Relations Contact:         Matthew H. Clawson         Partner, Allen & Caron, Inc.         Tel (949) 474-4300

CombiMatrix Corporation

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