American CareSource Holdings, Inc. (NASDAQ: ANCI), the nation’s leading ancillary health care system, announced today that the Board of Directors has appointed Board Member William J. Simpson, Jr. of Dallas, Texas, Chief Operating Officer effective immediately.

“I’m excited about the opportunity to become part of the executive team at American CareSource Holdings,” said Mr. Simpson. “The Company is a pioneer in the ancillary care services market and has a solid track record of successfully delivering cost savings to its clients. I look forward to generating efficiencies in the business that will further enhance the services we offer."

Commenting on Mr. Simpson’s appointment, President and Chief Executive Officer, David S. Boone said, "It is with great pleasure that we welcome Mr. Simpson to our executive team. His extensive industry experience and strong operational background will be a significant addition to our Company. His participation will allow me to better focus my efforts externally, which includes developing new client relationships, expanding our product offerings, and exploring potential mergers and acquisition candidates for the Company. I am looking forward to working closely with Bill as we grow our Company in 2011."

Mr. Simpson is an experienced executive and business leader. He is the former President, Chief Executive Officer and Director of Intrepid USA Healthcare Inc. In addition, he has served on multiple boards, including Genezen Healthcare, where he was Chairman, and ALTHA. In addition Mr. Simpson had held a number of executive management positions including Executive Vice President and Chief Operating Officer at LifeCare, Executive Vice President and Chief Operating Officer at Specialty Healthcare Services, Executive Vice President of Operations at Intensiva Healthcare Corporation, President and Chief Operating Officer at Ameristat Mobile Medical Services, President of Epic Healthcare Services, and Vice President of American Medical International.

About American CareSource Holdings, Inc.

American CareSource Holdings, Inc., the first national, publicly traded ancillary care network services company, offers a comprehensive national network of over 4,100 ancillary service providers at more than 38,000 sites through its subsidiary, Ancillary Care Services. Ancillary Care Services provides ancillary health care services through its network that offers cost effective alternatives to physician and hospital-based services. This market is estimated at $574 billion and has grown to over 20% of total national health expenditures. These providers offer services in 31 categories including laboratories, dialysis centers, free-standing diagnostic imaging centers, non-hospital surgery centers, as well as durable medical equipment such as orthotics and prosthetics and others.

The Company's ancillary network and management provides a complete outsourced solution for a wide variety of health care payors and plan sponsors including self-insured employers, indemnity insurers, preferred provider organizations, health maintenance organizations, third party administrators and both federal and local governments. For additional information, please visit www.anci-care.com.

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Safe Harbor Statement Under the Private Securities Litigation Reform Act of 1995:

Any statements that are not historical facts contained in this release, including with respect to future engagements by clients, revenue growth, earnings, and guidance are forward-looking statements. It is possible that the assumptions made by American CareSource Holdings, Inc. for purposes of such statements may prove to be inaccurate or may not materialize. Actual results may differ materially from those projected or implied in any forward-looking statements. Such statements may involve further risks and uncertainties, including but not limited to those relating to demand for our services, pricing, market acceptance, our ability to integrate with our clients, our ability to attract and maintain providers, our ability to manage growth, the effect of economic, political and regulatory conditions, the effect of competition, risks in product development, the ability to complete transactions, and other risks identified in this release, and the Securities and Exchange Commission filings of American CareSource Holdings, Inc.

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