NEW YORK ( TheStreet) -- The latest quarterly disclosures of investment heavyweights like Warren Buffett and John Paulson have by now been extensively covered. The question for investors now is which investment guru should they follow? Who made the wisest pick?

Users of TheStreet who took our poll would still prefer to place their bets with Buffett's latest pick over those of other investment managers, though George Soros came in a close second.

Readers were asked which market heavyweight they thought made the wisest pick, based on their top new buys. Out of the more than 435 readers who took the poll, 29% said they thought Warren Buffett made the wisest move with his latest addition, Bank of New York Mellon ( BK).

The world's largest custody bank has been in an acquisition mode, buying PNC Global Investment Servicing, which serves the asset management industry. It also bought Canadian wealth advisory services company i3. But Mellon might itself be an attractive target for larger banks looking to expand their wealth management business. The stock is up 10% in the last three months and trades at a price-earnings multiple of 13.5.

George Soros' Dendreon ( DNDN) was also popular with readers, garnering 26% of the votes. Dendreon shares are up 40% year to date. Shares got a further lift last week after a medicare panel endorsed the on-label use of its prostate cancer drug, Provenge. Medicare sales would generate $1.7 billion a year for Dendreon by 2014.

David Einhorn's well-known short position in St.Joe ( JOE) came in third, with 15% of the votes. A 13F filing normally reveals only long equity positions, but Einhorn disclosed his short position in the stock last month in an elaborate presentation at the Value Investing Congress.

The hedge fund manager said the company would have to take more write-downs as its real estate assets in Florida were nothing more than a "deserted swampland." That pitted him against deep-value investor Bruce Berkowitz, who went on to buy more of the stock. In an interview with TheStreet, Berkowitz said, "If David wants to create an asset at a cheaper price for me to buy, thank you."

The vote was evenly split between David Tepper's Hewlett Packard ( HPQ) and John Paulson's Anadarko Petroleum ( APC), each getting 64 votes, or slightly less than 15% of the total. Tepper notably added large-cap tech stocks to his portfolio even as he cut back on financials. Both stocks have been up on good news lately. Hewlett Packard on Monday said its profits rose 17% to $1.33 per share, beating estimates by 6 cents. Anadarko also announced Monday that it had made a "substantial discovery" off Brazil's coast.

-- Written by Shanthi Bharatwaj in New York

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