LifeSci Advisors, LLC, a leading provider of investment research and investor relations services in the life sciences sector, today announced that it has initiated coverage of Genta Incorporated (OTCBB: GNTA.OB), a biopharmaceutical company with a diversified product portfolio that is focused on delivering innovative products for the treatment of patients with cancer. “Genta is currently advancing tesetaxel, the leading oral taxane in clinical development, in multiple cancer indications. A Phase III trial design for tesetaxel has been submitted to FDA for a Special Protocol Assessment (SPA) in advanced gastric cancer, where tesetaxel has already demonstrated strong anti-cancer activity and there is a significant unmet medical need,” commented Andrew I. McDonald, Ph.D., Managing Director at LifeSci Advisors. “In addition to tesetaxel, many investors associate Genta with Genasense®, whose prospects in the ongoing AGENDA Phase III melanoma trial have been largely discounted following disappointing interim results, but Genasense® still represents a significant opportunity. A detailed analysis of data and statistics for Genasense® in the report support our cautious optimism that the drug might still hit the important overall survival (OS) endpoint despite missing on Progression Free Survival (PFS). The current situation with Genasense® is analogous to the recent Provenge® story with Dendreon in prostate cancer, and Bristol-Myers Squibb’s ipilimumab in melanoma, both of which also recently hit on OS after missing on PFS.” LifeSci Advisors’ 63-page Initiation Report discusses in depth Genta’s lead drug candidates in development. These include: tesetaxel, a novel, orally absorbed taxane in the same drug class as paclitaxel and docetaxel; Genasense® (oblimersen sodium injection), which is a modified DNA-based antisense Bcl-2 inhibitor drug that may enhance the effectiveness of anticancer therapy; and oral gallium, which is being evaluated as potential treatment for diseases associated with accelerated bone loss. Tesetaxel has shown activity against multiple tumor types during the 5 Phase II studies that have been completed, with additional Phase II studies ongoing or planned. The company has announced their intention to pursue advanced gastric cancer as the lead indication for tesetaxel, and is working to finalize a Phase III study design for tesetaxel in that indication based on guidance from regulatory agencies in the US and Europe. Final overall survival data is expected from Genta’s Phase III AGENDA trial for Genasense® in 1H2011. In addition, Genta is developing an oral formulation of their marketed product Ganite® (gallium nitrate injection), which is marketed in the U.S. and is indicated for treatment of symptomatic patients with cancer-related hypercalcemia that is resistant to hydration. The oral gallium products, with their improved convenience and pharmacokinetics, have potential to treat several bone loss indications with large unmet needs, including bone metastases, Paget’s disease and osteoporosis. Further included in the report is a complete background of Genta’s clinical programs, their clinical performances to date, competitive landscapes, upcoming expected milestones, market dynamics upon approval, and associated risks.
Dr. McDonald’s full Initiation Report is available to download at no cost at the LifeSci Advisors website, www.lifesciadvisors.com. In addition to this Initiation Report, LifeSci Advisors will also provide ongoing coverage and event-based research updates on Genta as developments occur.The LifeSci Advisors research team is led by Dr. Andrew I. McDonald, an industry veteran with more than 15 years of healthcare industry experience. Prior to co-founding LSA, Dr. McDonald was the Senior Biotechnology Analyst at Great Point Partners, a leading health care investment firm with over $500 million under management. Before Great Point, he was Co-head of Healthcare Research and Lead Biotechnology Analyst at ThinkEquity Partners, a boutique investment banking firm focused on growth companies. Dr. McDonald holds a Ph.D. in organic chemistry from the University of California, Irvine, and, earlier in his career, worked as a medicinal chemist at both Pfizer and Cytokinetics. About LifeSci Advisors: LifeSci Advisors (LSA) is a leading research firm and communications consultancy dedicated to the life sciences industry. The firm provides strategic counsel, customized marketing communications, comprehensive research reports and investor relations services to companies that specialize in the discovery, development and commercialization of drugs, drug delivery systems, medical devices and diagnostics. To learn more about LSA, visit the company’s website, www.lifesciadvisors.com. Important Disclosures: The research report described in this press release is not intended as an offering, recommendation, or a solicitation of an offer to buy or sell securities. The securities discussed in LSA research reports may be unsuitable for some investors depending on their specific investment objectives, financial status, risk profile, or particular needs. Investors should consider LSA reports as only a single factor in making their investment decisions and should not rely solely on these reports in evaluating whether or not to buy or sell the securities of the subject company. LifeSci Advisors has been compensated by the company that is the subject of the report described and future research reports, investor relations services, and general consulting services. Please read each report's full disclosures and analyst background on the LSA website, www.lifesciadvisors.com, before investing. LifeSci Advisors is not a registered investment adviser or broker-dealer. Forward-looking statements: This press release contains forward-looking statements subject to risks and uncertainties that could cause actual results to differ materially from those projected. These forward-looking statements represent LSA's judgment as of the date of this release. LifeSci Advisors disclaims, however, any intent or obligation to update these forward-looking statements.