The research reported in this paper is part of BioTime's broader research strategy to advance the capabilities of the company’s proprietary ReCyte technology. ReCyte is being developed as a means of implementing iPS technology on an industrial scale. The study published today intentionally used older viral-based means of introducing genes. Therefore, BioTime plans further studies of cellular aging reversal using its proprietary ReCyte technology. BioTime has filed new patent applications on methods used in the paper to reverse the developmental aging of cells and the use of transcriptional reprogramming to produce young cells of many types for use in regenerating tissues affected by aging.“This is just the beginning of some really fascinating new possibilities for intervening in age-related disease,” said Michael D. West, Ph.D., President and Chief Executive Officer of BioTime, Inc. “We believe that these technologies will have a significant impact on the future of medicine. However, it is important to underscore that much work needs to be done to translate these findings into safe and efficacious therapies.” “At the National Institute on Aging, we reviewed many proposals from leading gerontologists seeking means to understand and intervene in the biology of aging,” said Robert N. Butler, M.D., Founding Director of the National Institute on Aging, now President of the International Longevity Center, and Board member of BioTime. “These are just the type of basic discoveries that if funded on a larger scale, could help us ward off the enormous wave of health care expenditures coming our way as a result of the aging baby boom population.” Background Regenerative medicine refers to the development and use of therapies based on human embryonic stem (hES) cell or induced pluripotent stem (iPS) cell technology. These therapies will be designed to regenerate tissues afflicted by degenerative diseases. The great scientific and public interest in regenerative medicine lies in the potential of hES and iPS cells to become all of the cell types of the human body. Many scientists therefore believe that hES and iPS cells have considerable potential as sources of new therapies for a host of currently incurable diseases such as diabetes, Parkinson’s disease, heart failure, arthritis, muscular dystrophy, spinal cord injury, macular degeneration, hearing loss, liver failure, and many other disorders where cells and tissues become dysfunctional and need to be replaced.
Since human embryonic stem cells are derived from discarded human embryos created in the process of in vitro fertilization (IVF), their use in research has been controversial. However, induced pluripotent (iPS) stem cells can be created using noncontroversial adult cells, such as skin cells, rather than embryonic cells. The alteration of specific genes in adult cells allows them to be transformed into iPS cells that are very similar to hES cells.BioTime plans to eventually utilize these technologies for human therapeutic applications. However, the technologies reported in BioTime’s scientific article are early stage research findings. Cell-based therapeutics require years of extensive preclinical testing and development prior to being used in an effort to treat humans. Where More Information Can Be Found The article is published online at http://www.futuremedicine.com/doi/abs/10.2217/rme.10.21. The authors of the article include: Dr. Homayoun Vaziri, Andriana Guigova, and Jonathan Teichroeb of the Ontario Cancer Institute; Ilyas Singec and Evan Snyder of the Burnham Institute for Medical Research; David Larocca of Mandala Biosciences, LLC; Laura Briggs, Jessica Wheeler, and William H. Andrews of Sierra Biosciences; Rodolfo Gonzales of the Scripps Research Institute; and Karen B. Chapman, Markus D. Lacher, Hal Sternberg, Walter D. Funk, and Michael D. West from BioTime, Inc. Additional information about the use of BioTime’s stem cell technology is available at www.biotimeinc.com. About BioTime, Inc. BioTime, headquartered in Alameda, California, is a biotechnology company focused on regenerative medicine and blood plasma volume expanders. BioTime develops and markets research products in the field of stem cells and regenerative medicine through its wholly owned subsidiary Embryome Sciences, Inc. BioTime’s subsidiary OncoCyte Corporation focuses on the therapeutic applications of stem cell technology in cancer. BioTime also plans to develop therapeutic products in China for the treatment of ophthalmologic, skin, musculo-skeletal system and hematologic diseases, including the targeting of genetically modified stem cells to tumors as a novel means of treating currently incurable forms of cancer through its subsidiary BioTime Asia. In addition to its stem cell products, BioTime develops blood plasma volume expanders, blood replacement solutions for hypothermic (low temperature) surgery, and technology for use in surgery, emergency trauma treatment and other applications. BioTime's lead product, Hextend ®, is a blood plasma volume expander manufactured and distributed in the U.S. by Hospira, Inc. and in South Korea by CJ CheilJedang Corp. under exclusive licensing agreements. Additional information about BioTime can be found on the web at www.biotimeinc.com. Forward-Looking Statements Statements pertaining to future financial and/or operating results, future growth in research, technology, clinical development and potential opportunities for the company and its subsidiaries, along with other statements about the future expectations, beliefs, goals, plans, or prospects expressed by management constitute forward-looking statements. Any statements that are not historical fact (including, but not limited to statements that contain words such as “will,” “believes,” “plans,” “anticipates,” “expects,” “estimates,”) should also be considered to be forward-looking statements. Forward-looking statements involve risks and uncertainties, including, without limitation, risks inherent in the development and/or commercialization of potential products, uncertainty in the results of clinical trials or regulatory approvals, need and ability to obtain future capital, and maintenance of intellectual property rights. Actual results may differ materially from the results anticipated in these forward-looking statements and as such should be evaluated together with the many uncertainties that affect the company's business, particularly those mentioned in the cautionary statements found in the company's Securities and Exchange Commission filings. The company disclaims any intent or obligation to update these forward-looking statements. To receive ongoing BioTime corporate communications, please click on the following link to join our email alert list: http://www.b2i.us/irpass.asp?BzID=1152&to=ea&s=0