Affymetrix, Inc. (NASDAQ:AFFX) announced today that Jami Dover Nachtsheim and Nelson C. Chan have been appointed to the board of directors, effective March 8, 2010. The board appointed Ms. Nachtsheim to the Compensation Committee and Mr. Chan to the Audit Committee.

The company also announced that John A. Young will retire from the board of directors on Affymetrix on May 14, 2010, the date of the company’s 2010 annual meeting of stockholders, after completing his current term.

“We thank John for his 18 years of service on the board. We highly value his broad business experience and leadership of the board and we wish him well in his retirement,” said Stephen P.A. Fodor, PhD, founder and executive chairman of Affymetrix. “We are very pleased to add Jami Dover Nachtsheim and Nelson Chan to our board of directors. Their business backgrounds and experiences as public company directors will enable them to make immediate contributions to our business and marketing strategies.”

Jami Dover Nachtsheim held a variety of positions with Intel Corporation from 1980 until her retirement in 2000, most recently as Corporate Vice President of the Sales and Marketing Group and Director of Worldwide Marketing. Ms. Nachtsheim currently serves on the board of directors of Southwall Technologies, ACT Conferencing, and the Tech Museum of Innovation.

Nelson C. Chan served as Chief Executive Officer of Magellan Navigation, Inc. from 2006 to 2008. From 1992 to 2006, Mr. Chan held various senior management positions with SanDisk Corporation, most recently Executive Vice President and General Manager, Consumer Business. Mr. Chan currently serves on the board of directors of Silicon Labs and Synaptics, Inc.

About Affymetrix

Affymetrix technology is used by the world’s top pharmaceutical, diagnostic, and biotechnology companies, as well as leading academic, government, and nonprofit research institutes. More than 1,800 systems have been shipped around the world and more than 20,000 peer-reviewed papers have been published using the technology.

Affymetrix is headquartered in Santa Clara, Calif., and has manufacturing facilities in Cleveland, Ohio, and Singapore. The company has about 1,100 employees worldwide and maintains sales and distribution operations across Europe and Asia. For more information about Affymetrix, please visit the company’s website at www.affymetrix.com.

Forward-looking statements

All statements in this press release that are not historical are “forward-looking statements” within the meaning of Section 21E of the Securities Exchange Act as amended, including statements regarding Affymetrix’ “expectations,” “beliefs,” “hopes,” “intentions,” “strategies,” or the like. Such statements are subject to risks and uncertainties that could cause actual results to differ materially for Affymetrix from those projected. These and other risk factors are discussed in Affymetrix’ Form 10-K for the year ended December 31, 2009, and other SEC reports for subsequent quarterly periods.

Affymetrix, the Affymetrix logo, and GeneChip ® are registered trademarks of Affymetrix Inc. All other trademarks are property of their respective owners.

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