The S&P 500 is off roughly 40% since its October 2007 peak of 1,550, signaling the worst bear-market since 1933. But there are always stocks and companies that buck the prevailing trend of analyst and investor estimates, both on the upside and downside.

Even in this volatile market, this includes stocks making 52-week highs and lows. Recently, such stocks as Netease.com ( NTES) and Siga Technologies ( SIGA) are making new highs, and stocks including Abbott ( ABT) and Arena ( ARNA) are making new lows.

Let's take a closer look at a few of these stocks.

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