Updated from 12:28 p.m. EDTThe S&P 500 is off roughly 48% since its October 2007 peak of 1,550, signaling the worst bear-market since 1933. But there are always stocks and companies that buck the prevailing trend of analyst and investor estimates, both on the upside and downside. Even in this volatile market, this includes stocks making 52-week highs and 52-week lows. Recently, such stocks as Myriad Genetics ( MYGN) and Family Dollar ( FDO) were hitting new highs, while Express Scripts ( ESRX) hit a new low. Let's take a closer look at a few of these stocks. To read more, visit Stockpickr.com.